Genetic Safeguards for Safety-by-design: So Close Yet So Far

E. Asin-Garcia, Amalia Kallergi, Laurens Landeweerd, V.A.P. Martins dos Santos*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)


Safety-by-design (SbD) is paramount for risk management in synthetic biology, with genetic safeguards being a key technology for its implementation. While attractive in theory, the integration of genetic safeguards into SbD strategies is rarely exercised in practice, despite technological advances. Here we question why and what might be done about it.
Original languageEnglish
Pages (from-to)1308-1312
JournalTrends in Biotechnology
Issue number12
Early online date10 May 2020
Publication statusPublished - Dec 2020


  • biocontainment
  • biosafety
  • genetic safeguards
  • safety-by-design
  • synthetic biology


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