Genetic Safeguards for Safety-by-design: So Close Yet So Far

E. Asin-Garcia; Amalia Kallergi; Laurens  Landeweerd; V.A.P. Martins dos Santos

doi:10.1016/j.tibtech.2020.04.005

Genetic Safeguards for Safety-by-design: So Close Yet So Far

E. Asin-Garcia, Amalia Kallergi, Laurens Landeweerd, V.A.P. Martins dos Santos^*

^*Corresponding author for this work

Systems and Synthetic Biology

Research output: Contribution to journal › Article › Academic › peer-review

21 Citations (Scopus)

Abstract

Safety-by-design (SbD) is paramount for risk management in synthetic biology, with genetic safeguards being a key technology for its implementation. While attractive in theory, the integration of genetic safeguards into SbD strategies is rarely exercised in practice, despite technological advances. Here we question why and what might be done about it.

Original language	English
Pages (from-to)	1308-1312
Journal	Trends in Biotechnology
Volume	38
Issue number	12
Early online date	10 May 2020
DOIs	https://doi.org/10.1016/j.tibtech.2020.04.005
Publication status	Published - Dec 2020

Keywords

biocontainment
biosafety
genetic safeguards
safety-by-design
synthetic biology

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10.1016/j.tibtech.2020.04.005

MycoSynVac: Engineering of Mycoplasma pneumoniae as a broad-spectrum animal vaccine
1/04/15 → 31/03/20
Project: EU research project

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title = "Genetic Safeguards for Safety-by-design: So Close Yet So Far",

abstract = "Safety-by-design (SbD) is paramount for risk management in synthetic biology, with genetic safeguards being a key technology for its implementation. While attractive in theory, the integration of genetic safeguards into SbD strategies is rarely exercised in practice, despite technological advances. Here we question why and what might be done about it.",

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KW - biosafety

KW - genetic safeguards

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Genetic Safeguards for Safety-by-design: So Close Yet So Far

Abstract

Keywords

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Projects

MycoSynVac: Engineering of Mycoplasma pneumoniae as a broad-spectrum animal vaccine

Cite this