Safety-by-design (SbD) is paramount for risk management in synthetic biology, with genetic safeguards being a key technology for its implementation. While attractive in theory, the integration of genetic safeguards into SbD strategies is rarely exercised in practice, despite technological advances. Here we question why and what might be done about it.
Asín García, E., Kallergi, A., Landeweerd, L., & Martins dos Santos, V. A. P. (2020). Genetic Safeguards for Safety-by-design: So Close Yet So Far. Trends in Biotechnology, . https://doi.org/10.1016/j.tibtech.2020.04.005