Genetic parameters for levels of natural antibodies in chicken lines divergently selected for specific antibody response

S. Wijga, H.K. Parmentier, M.G.B. Nieuwland, H. Bovenhuis

Research output: Contribution to journalArticleAcademicpeer-review

25 Citations (Scopus)

Abstract

The present study estimated the heritability of natural antibody (NAb) levels binding rabbit red blood cells at the day of immunization with SRBC (NAb0) and 5 d postimmunization (NAb5) in 2 chicken lines divergently selected for specific antibody levels (SpAb) against SRBC and a randombred control line. In addition, genetic correlations between the levels of NAb binding rabbit red blood cells and levels of SpAb binding SRBC were estimated. The heritability of the SpAb level against SRBC was estimated based on data from 23 generations of selection and in total 21,842 chickens. The heritability of NAb levels against rabbit red blood cells was estimated on 1,764 chickens in generations 22 and 23 using a bivariate analysis including the trait under selection (i.e., SpAb responses to SRBC). Maternal environmental effects were accounted for in the analyses. The heritability for SpAb was 0.17, the heritability for NAb0 levels was 0.23, and the heritability for NAb5 was 0.09. The genetic correlation between SpAb and NAb0 was 0.15 and the genetic correlation between SpAb and NAb5 was 0.50. The weak, though positive, genetic correlation between SpAb responses and the NAb0 levels in nonimmunized chickens, as well as the moderate genetic correlation between SpAb responses and the NAb levels 5 d postimmunization with SRBC, suggest that selection for enhanced adaptive immune system results in a positive correlated response of the innate immunity of chickens
Original languageEnglish
Pages (from-to)1805-1810
JournalPoultry Science
Volume88
Issue number9
DOIs
Publication statusPublished - 2009

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chickens
antibodies
heritability
genetic correlation
erythrocytes
rabbits
correlated responses
immunization

Keywords

  • directional selection
  • sheep erythrocytes
  • cells
  • antigen
  • traits
  • immunogenicity
  • complement
  • epitopes
  • immunity
  • innate

Cite this

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title = "Genetic parameters for levels of natural antibodies in chicken lines divergently selected for specific antibody response",
abstract = "The present study estimated the heritability of natural antibody (NAb) levels binding rabbit red blood cells at the day of immunization with SRBC (NAb0) and 5 d postimmunization (NAb5) in 2 chicken lines divergently selected for specific antibody levels (SpAb) against SRBC and a randombred control line. In addition, genetic correlations between the levels of NAb binding rabbit red blood cells and levels of SpAb binding SRBC were estimated. The heritability of the SpAb level against SRBC was estimated based on data from 23 generations of selection and in total 21,842 chickens. The heritability of NAb levels against rabbit red blood cells was estimated on 1,764 chickens in generations 22 and 23 using a bivariate analysis including the trait under selection (i.e., SpAb responses to SRBC). Maternal environmental effects were accounted for in the analyses. The heritability for SpAb was 0.17, the heritability for NAb0 levels was 0.23, and the heritability for NAb5 was 0.09. The genetic correlation between SpAb and NAb0 was 0.15 and the genetic correlation between SpAb and NAb5 was 0.50. The weak, though positive, genetic correlation between SpAb responses and the NAb0 levels in nonimmunized chickens, as well as the moderate genetic correlation between SpAb responses and the NAb levels 5 d postimmunization with SRBC, suggest that selection for enhanced adaptive immune system results in a positive correlated response of the innate immunity of chickens",
keywords = "directional selection, sheep erythrocytes, cells, antigen, traits, immunogenicity, complement, epitopes, immunity, innate",
author = "S. Wijga and H.K. Parmentier and M.G.B. Nieuwland and H. Bovenhuis",
year = "2009",
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language = "English",
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Genetic parameters for levels of natural antibodies in chicken lines divergently selected for specific antibody response. / Wijga, S.; Parmentier, H.K.; Nieuwland, M.G.B.; Bovenhuis, H.

In: Poultry Science, Vol. 88, No. 9, 2009, p. 1805-1810.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Genetic parameters for levels of natural antibodies in chicken lines divergently selected for specific antibody response

AU - Wijga, S.

AU - Parmentier, H.K.

AU - Nieuwland, M.G.B.

AU - Bovenhuis, H.

PY - 2009

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N2 - The present study estimated the heritability of natural antibody (NAb) levels binding rabbit red blood cells at the day of immunization with SRBC (NAb0) and 5 d postimmunization (NAb5) in 2 chicken lines divergently selected for specific antibody levels (SpAb) against SRBC and a randombred control line. In addition, genetic correlations between the levels of NAb binding rabbit red blood cells and levels of SpAb binding SRBC were estimated. The heritability of the SpAb level against SRBC was estimated based on data from 23 generations of selection and in total 21,842 chickens. The heritability of NAb levels against rabbit red blood cells was estimated on 1,764 chickens in generations 22 and 23 using a bivariate analysis including the trait under selection (i.e., SpAb responses to SRBC). Maternal environmental effects were accounted for in the analyses. The heritability for SpAb was 0.17, the heritability for NAb0 levels was 0.23, and the heritability for NAb5 was 0.09. The genetic correlation between SpAb and NAb0 was 0.15 and the genetic correlation between SpAb and NAb5 was 0.50. The weak, though positive, genetic correlation between SpAb responses and the NAb0 levels in nonimmunized chickens, as well as the moderate genetic correlation between SpAb responses and the NAb levels 5 d postimmunization with SRBC, suggest that selection for enhanced adaptive immune system results in a positive correlated response of the innate immunity of chickens

AB - The present study estimated the heritability of natural antibody (NAb) levels binding rabbit red blood cells at the day of immunization with SRBC (NAb0) and 5 d postimmunization (NAb5) in 2 chicken lines divergently selected for specific antibody levels (SpAb) against SRBC and a randombred control line. In addition, genetic correlations between the levels of NAb binding rabbit red blood cells and levels of SpAb binding SRBC were estimated. The heritability of the SpAb level against SRBC was estimated based on data from 23 generations of selection and in total 21,842 chickens. The heritability of NAb levels against rabbit red blood cells was estimated on 1,764 chickens in generations 22 and 23 using a bivariate analysis including the trait under selection (i.e., SpAb responses to SRBC). Maternal environmental effects were accounted for in the analyses. The heritability for SpAb was 0.17, the heritability for NAb0 levels was 0.23, and the heritability for NAb5 was 0.09. The genetic correlation between SpAb and NAb0 was 0.15 and the genetic correlation between SpAb and NAb5 was 0.50. The weak, though positive, genetic correlation between SpAb responses and the NAb0 levels in nonimmunized chickens, as well as the moderate genetic correlation between SpAb responses and the NAb levels 5 d postimmunization with SRBC, suggest that selection for enhanced adaptive immune system results in a positive correlated response of the innate immunity of chickens

KW - directional selection

KW - sheep erythrocytes

KW - cells

KW - antigen

KW - traits

KW - immunogenicity

KW - complement

KW - epitopes

KW - immunity

KW - innate

U2 - 10.3382/ps.2009-00064

DO - 10.3382/ps.2009-00064

M3 - Article

VL - 88

SP - 1805

EP - 1810

JO - Poultry Science

JF - Poultry Science

SN - 0032-5791

IS - 9

ER -