Genetic improvement of canine hip dysplasia through sire selection across countries

S. Wang*, E. Strandberg, Viklund, J.J. Windig, S. Malm, T. Lewis, D. Laloë, G. Leroy

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Breeding against canine hip dysplasia (HD) may benefit from the importation of foreign sires. When foreign sires are evaluated on a different HD scale, this may diminish the efficacy. Using stochastic simulations, we evaluated genetic change and inbreeding levels for different scenarios of importing sires with high genetic merit for HD. Population size and genetic parameters (e.g. heritability, accuracy of selection, genetic correlation) were based on actual data for HD in Golden retrievers and Labrador retrievers in the UK and Sweden. For countries with different HD scales and an estimated breeding value (EBV) evaluation in place, the importation was useful if imported sires had EBV rankings in the top 50% and if genetic correlations between EBV systems were above 0.85. When importing sires with EBV rankings in the top 10%, moderate accuracies of EBVs (>0.40) and moderately strong genetic correlations (>0.70) were needed. Selection against HD without the importation of sires may increase inbreeding levels, while the importation of sires can decrease inbreeding levels. For national genetic evaluation and selection programmes, importing sires with high genetic merit can be an effective breeding strategy, but care is needed to estimate reliable EBVs.

Original languageEnglish
Pages (from-to)18-24
Number of pages7
JournalVeterinary Journal
Volume248
DOIs
Publication statusPublished - 1 Jun 2019

Fingerprint

Canine Hip Dysplasia
canine hip dysplasia
Hip Dislocation
genetic improvement
sires
Breeding
hip dysplasia
Inbreeding
breeding value
inbreeding
genetic correlation
Human Herpesvirus 4
genetic merit
Newfoundland and Labrador
Program Evaluation
Population Genetics
Population Density
Sweden
Golden Retriever
Labrador Retriever

Keywords

  • Canine
  • Estimated breeding value
  • Hip dysplasia
  • International breeding programme
  • Stochastic simulation

Cite this

Wang, S. ; Strandberg, E. ; Viklund, ; Windig, J.J. ; Malm, S. ; Lewis, T. ; Laloë, D. ; Leroy, G. / Genetic improvement of canine hip dysplasia through sire selection across countries. In: Veterinary Journal. 2019 ; Vol. 248. pp. 18-24.
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title = "Genetic improvement of canine hip dysplasia through sire selection across countries",
abstract = "Breeding against canine hip dysplasia (HD) may benefit from the importation of foreign sires. When foreign sires are evaluated on a different HD scale, this may diminish the efficacy. Using stochastic simulations, we evaluated genetic change and inbreeding levels for different scenarios of importing sires with high genetic merit for HD. Population size and genetic parameters (e.g. heritability, accuracy of selection, genetic correlation) were based on actual data for HD in Golden retrievers and Labrador retrievers in the UK and Sweden. For countries with different HD scales and an estimated breeding value (EBV) evaluation in place, the importation was useful if imported sires had EBV rankings in the top 50{\%} and if genetic correlations between EBV systems were above 0.85. When importing sires with EBV rankings in the top 10{\%}, moderate accuracies of EBVs (>0.40) and moderately strong genetic correlations (>0.70) were needed. Selection against HD without the importation of sires may increase inbreeding levels, while the importation of sires can decrease inbreeding levels. For national genetic evaluation and selection programmes, importing sires with high genetic merit can be an effective breeding strategy, but care is needed to estimate reliable EBVs.",
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author = "S. Wang and E. Strandberg and Viklund and J.J. Windig and S. Malm and T. Lewis and D. Lalo{\"e} and G. Leroy",
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Wang, S, Strandberg, E, Viklund, , Windig, JJ, Malm, S, Lewis, T, Laloë, D & Leroy, G 2019, 'Genetic improvement of canine hip dysplasia through sire selection across countries', Veterinary Journal, vol. 248, pp. 18-24. https://doi.org/10.1016/j.tvjl.2019.03.009

Genetic improvement of canine hip dysplasia through sire selection across countries. / Wang, S.; Strandberg, E.; Viklund, ; Windig, J.J.; Malm, S.; Lewis, T.; Laloë, D.; Leroy, G.

In: Veterinary Journal, Vol. 248, 01.06.2019, p. 18-24.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Wang, S.

AU - Strandberg, E.

AU - Viklund, null

AU - Windig, J.J.

AU - Malm, S.

AU - Lewis, T.

AU - Laloë, D.

AU - Leroy, G.

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KW - Hip dysplasia

KW - International breeding programme

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