Genetic analysis

M. Koornneef, C. Alonso-Blanco, P. Stam

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)


The Mendelian analysis of genetic variation, available as induced mutants or as natural variation, requires a number of steps that are described in this chapter. These include the determination of the number of genes involved in the observed trait's variation, the determination of dominance relationships between alleles of the same locus, and epistatic interactions with related genetic variants. A new variant should be compared with previously identified genetic variants, which is most efficiently done by allelism tests in case of recessive mutants. In addition the locus should be localized on the genetic and physical map by linkage analysis. The mapping of mutant loci in Arabidopsis is facilitated by the genomic resources available in Arabidopsis and often consists of two steps, a crude and a fine mapping, the latter enabling the approximate location of a variant on the sequence map of Arabidopsis
Original languageEnglish
Title of host publicationMethods in Molecular Biology
Subtitle of host publicationArabidopsis Protocols
EditorsJ. Salinas, J.J. Sanchez-Serrano
Place of PublicationTotowa, New Jersey
PublisherHumana Press
ISBN (Electronic)9781597450034
ISBN (Print)9781588293954
Publication statusPublished - 2006

Publication series

NameMethods in Molecular Biology
PublisherHumana press
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

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    Koornneef, M., Alonso-Blanco, C., & Stam, P. (2006). Genetic analysis. In J. Salinas, & J. J. Sanchez-Serrano (Eds.), Methods in Molecular Biology: Arabidopsis Protocols (Vol. 323, pp. 65-77). (Methods in Molecular Biology; Vol. 323). Humana Press.