Generation of LTB-based mucosal vaccines and production in plants

D.E.A. Florack, C.I. Matos, G.J.A. Rouwendal, H.J. Bosch

    Research output: Contribution to journalAbstractAcademic

    1 Citation (Scopus)


    A number of recombinant B subunit-fusion proteins comprising either small and linear B and/or T cell epitope sequences, a large structural N-glycosylated viral surface antigen and two reporter enzymatic entities were expressed in potato tubers. All could be functionally expressed as determined by a GM1-ELISA but actual levels varied significantly and decreased strongly upon increased complexity
    Original languageEnglish
    Pages (from-to)399-400
    JournalJournal of Controlled Release
    Issue number1-3
    Publication statusPublished - 2005


    • transgenic plants
    • oral immunization
    • cholera-toxin
    • subunit


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