Gene Expression Modifications by Temperature-Toxicants Interactions in Caenorhabditis elegans

A. Vinuela Rodriguez, L.B. Snoek, J.A.G. Riksen, J.E. Kammenga

Research output: Contribution to journalArticleAcademicpeer-review

13 Citations (Scopus)


Although organophosphorus pesticides (OP) share a common mode of action, there is increased awareness that they elicit a diverse range of gene expression responses. As yet however, there is no clear understanding of these responses and how they interact with ambient environmental conditions. In the present study, we investigated genome-wide gene expression profiles in the nematode Caenorhabditis elegans exposed to two OP, chlorpyrifos and diazinon, in single and combined treatments at different temperatures. Our results show that chlorpyrifos and diazinon induced expression of different genes and that temperature affected the response of detoxification genes to the pesticides. The analysis of transcriptional responses to a combination of chlorpyrifos and diazinon shows interactions between toxicants that affect gene expression. Furthermore, our combined analysis of the transcriptional responses to OP at different temperatures suggests that the combination of OP and high temperatures affect detoxification genes and modified the toxic levels of the pesticides
Original languageEnglish
Article numbere24676
Number of pages11
JournalPLoS ONE
Issue number9
Publication statusPublished - 2011


  • zebrafish-danio-rerio
  • cdna microarray data
  • organophosphorus pesticides
  • developmental neurotoxicity
  • chemical-mixtures
  • binary-mixtures
  • heat-stress
  • c-elegans
  • toxicity
  • chlorpyrifos


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