Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study

Aurelia Santoro, Giulia Guidarelli, Rita Ostan, Enrico Giampieri, Cristina Fabbri, Claudia Bertarelli, Claudio Nicoletti, Fawzi Kadi, Lisette C.P.G.M. De Groot, Edith Feskens, Agnes Berendsen, Anna Brzozowska, Olga Januszko, Katarzyna Kozlowska, Susan Fairweather-Tait, Amy Jennings, Nathalie Meunier, Elodie Caumon, Alessandro Napoli, Daniele Mercatelli & 4 others Giuseppe Battista, Miriam Capri, Claudio Franceschi, Alberto Bazzocchi

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

ObjectivesThe aim of this work was to examine the cross-sectional relationship between body composition (BC) markers for adipose and lean tissue and bone mass, and a wide range of specific inflammatory and adipose-related markers in healthy elderly Europeans. Methods A whole-body dual-energy X-ray absorptiometry (DXA) scan was made in 1121 healthy (65–79 years) women and men from five European countries of the “New dietary strategies addressing the specific needs of elderly population for a healthy aging in Europe” project (NCT01754012) cohort to measure markers of adipose and lean tissue and bone mass. Pro-inflammatory (IL-6, IL-6Rα, TNF-α, TNF-R1, TNF-R2, pentraxin 3, CRP, alpha-1-acid glycoprotein, albumin) and anti-inflammatory (IL-10, TGF-β1) molecules as well as adipose-related markers such as leptin, adiponectin, ghrelin, and resistin were measured by magnetic bead-based multiplex-specific immunoassays and biochemical assays. Results BC characteristics were different in elderly women and men, and more favorable BC markers were associated with a better adipose-related inflammatory profile, with the exception of skeletal muscle mass index. No correlation was found with the body composition markers and circulating levels of some standard pro- and anti-inflammatory markers like IL-6, pentraxin 3, IL-10, TGF-β1, TNF-α, IL-6Rα, glycoprotein 130, TNF-α-R1, and TNF-α-R2.Conclusions The association between BC and inflammatory and adipose-related biomarkers is crucial in decoding aging and pathophysiological processes, such as sarcopenia. DXA can help in understanding how the measurement of fat and muscle is important, making the way from research to clinical practice.
LanguageEnglish
Pages4968-4979
JournalEuropean Radiology
Volume29
Issue number9
Early online date4 Feb 2019
DOIs
Publication statusPublished - Sep 2019

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Body Composition
Tumor Necrosis Factor-alpha
Receptors, Tumor Necrosis Factor, Type II
Photon Absorptiometry
Interleukin-10
Adipose Tissue
Interleukin-6
Anti-Inflammatory Agents
Sarcopenia
Resistin
Orosomucoid
Bone and Bones
Ghrelin
Adiponectin
Leptin
Immunoassay
Albumins
Glycoproteins
Skeletal Muscle
Biomarkers

Cite this

Santoro, Aurelia ; Guidarelli, Giulia ; Ostan, Rita ; Giampieri, Enrico ; Fabbri, Cristina ; Bertarelli, Claudia ; Nicoletti, Claudio ; Kadi, Fawzi ; De Groot, Lisette C.P.G.M. ; Feskens, Edith ; Berendsen, Agnes ; Brzozowska, Anna ; Januszko, Olga ; Kozlowska, Katarzyna ; Fairweather-Tait, Susan ; Jennings, Amy ; Meunier, Nathalie ; Caumon, Elodie ; Napoli, Alessandro ; Mercatelli, Daniele ; Battista, Giuseppe ; Capri, Miriam ; Franceschi, Claudio ; Bazzocchi, Alberto. / Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study. In: European Radiology. 2019 ; Vol. 29, No. 9. pp. 4968-4979.
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title = "Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study",
abstract = "ObjectivesThe aim of this work was to examine the cross-sectional relationship between body composition (BC) markers for adipose and lean tissue and bone mass, and a wide range of specific inflammatory and adipose-related markers in healthy elderly Europeans. Methods A whole-body dual-energy X-ray absorptiometry (DXA) scan was made in 1121 healthy (65–79 years) women and men from five European countries of the “New dietary strategies addressing the specific needs of elderly population for a healthy aging in Europe” project (NCT01754012) cohort to measure markers of adipose and lean tissue and bone mass. Pro-inflammatory (IL-6, IL-6Rα, TNF-α, TNF-R1, TNF-R2, pentraxin 3, CRP, alpha-1-acid glycoprotein, albumin) and anti-inflammatory (IL-10, TGF-β1) molecules as well as adipose-related markers such as leptin, adiponectin, ghrelin, and resistin were measured by magnetic bead-based multiplex-specific immunoassays and biochemical assays. Results BC characteristics were different in elderly women and men, and more favorable BC markers were associated with a better adipose-related inflammatory profile, with the exception of skeletal muscle mass index. No correlation was found with the body composition markers and circulating levels of some standard pro- and anti-inflammatory markers like IL-6, pentraxin 3, IL-10, TGF-β1, TNF-α, IL-6Rα, glycoprotein 130, TNF-α-R1, and TNF-α-R2.Conclusions The association between BC and inflammatory and adipose-related biomarkers is crucial in decoding aging and pathophysiological processes, such as sarcopenia. DXA can help in understanding how the measurement of fat and muscle is important, making the way from research to clinical practice.",
author = "Aurelia Santoro and Giulia Guidarelli and Rita Ostan and Enrico Giampieri and Cristina Fabbri and Claudia Bertarelli and Claudio Nicoletti and Fawzi Kadi and {De Groot}, {Lisette C.P.G.M.} and Edith Feskens and Agnes Berendsen and Anna Brzozowska and Olga Januszko and Katarzyna Kozlowska and Susan Fairweather-Tait and Amy Jennings and Nathalie Meunier and Elodie Caumon and Alessandro Napoli and Daniele Mercatelli and Giuseppe Battista and Miriam Capri and Claudio Franceschi and Alberto Bazzocchi",
year = "2019",
month = "9",
doi = "10.1007/s00330-018-5973-2",
language = "English",
volume = "29",
pages = "4968--4979",
journal = "European Radiology",
issn = "0938-7994",
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Santoro, A, Guidarelli, G, Ostan, R, Giampieri, E, Fabbri, C, Bertarelli, C, Nicoletti, C, Kadi, F, De Groot, LCPGM, Feskens, E, Berendsen, A, Brzozowska, A, Januszko, O, Kozlowska, K, Fairweather-Tait, S, Jennings, A, Meunier, N, Caumon, E, Napoli, A, Mercatelli, D, Battista, G, Capri, M, Franceschi, C & Bazzocchi, A 2019, 'Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study', European Radiology, vol. 29, no. 9, pp. 4968-4979. https://doi.org/10.1007/s00330-018-5973-2

Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study. / Santoro, Aurelia; Guidarelli, Giulia; Ostan, Rita; Giampieri, Enrico; Fabbri, Cristina; Bertarelli, Claudia; Nicoletti, Claudio; Kadi, Fawzi; De Groot, Lisette C.P.G.M.; Feskens, Edith; Berendsen, Agnes; Brzozowska, Anna; Januszko, Olga; Kozlowska, Katarzyna; Fairweather-Tait, Susan; Jennings, Amy; Meunier, Nathalie; Caumon, Elodie; Napoli, Alessandro; Mercatelli, Daniele; Battista, Giuseppe; Capri, Miriam; Franceschi, Claudio; Bazzocchi, Alberto.

In: European Radiology, Vol. 29, No. 9, 09.2019, p. 4968-4979.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study

AU - Santoro, Aurelia

AU - Guidarelli, Giulia

AU - Ostan, Rita

AU - Giampieri, Enrico

AU - Fabbri, Cristina

AU - Bertarelli, Claudia

AU - Nicoletti, Claudio

AU - Kadi, Fawzi

AU - De Groot, Lisette C.P.G.M.

AU - Feskens, Edith

AU - Berendsen, Agnes

AU - Brzozowska, Anna

AU - Januszko, Olga

AU - Kozlowska, Katarzyna

AU - Fairweather-Tait, Susan

AU - Jennings, Amy

AU - Meunier, Nathalie

AU - Caumon, Elodie

AU - Napoli, Alessandro

AU - Mercatelli, Daniele

AU - Battista, Giuseppe

AU - Capri, Miriam

AU - Franceschi, Claudio

AU - Bazzocchi, Alberto

PY - 2019/9

Y1 - 2019/9

N2 - ObjectivesThe aim of this work was to examine the cross-sectional relationship between body composition (BC) markers for adipose and lean tissue and bone mass, and a wide range of specific inflammatory and adipose-related markers in healthy elderly Europeans. Methods A whole-body dual-energy X-ray absorptiometry (DXA) scan was made in 1121 healthy (65–79 years) women and men from five European countries of the “New dietary strategies addressing the specific needs of elderly population for a healthy aging in Europe” project (NCT01754012) cohort to measure markers of adipose and lean tissue and bone mass. Pro-inflammatory (IL-6, IL-6Rα, TNF-α, TNF-R1, TNF-R2, pentraxin 3, CRP, alpha-1-acid glycoprotein, albumin) and anti-inflammatory (IL-10, TGF-β1) molecules as well as adipose-related markers such as leptin, adiponectin, ghrelin, and resistin were measured by magnetic bead-based multiplex-specific immunoassays and biochemical assays. Results BC characteristics were different in elderly women and men, and more favorable BC markers were associated with a better adipose-related inflammatory profile, with the exception of skeletal muscle mass index. No correlation was found with the body composition markers and circulating levels of some standard pro- and anti-inflammatory markers like IL-6, pentraxin 3, IL-10, TGF-β1, TNF-α, IL-6Rα, glycoprotein 130, TNF-α-R1, and TNF-α-R2.Conclusions The association between BC and inflammatory and adipose-related biomarkers is crucial in decoding aging and pathophysiological processes, such as sarcopenia. DXA can help in understanding how the measurement of fat and muscle is important, making the way from research to clinical practice.

AB - ObjectivesThe aim of this work was to examine the cross-sectional relationship between body composition (BC) markers for adipose and lean tissue and bone mass, and a wide range of specific inflammatory and adipose-related markers in healthy elderly Europeans. Methods A whole-body dual-energy X-ray absorptiometry (DXA) scan was made in 1121 healthy (65–79 years) women and men from five European countries of the “New dietary strategies addressing the specific needs of elderly population for a healthy aging in Europe” project (NCT01754012) cohort to measure markers of adipose and lean tissue and bone mass. Pro-inflammatory (IL-6, IL-6Rα, TNF-α, TNF-R1, TNF-R2, pentraxin 3, CRP, alpha-1-acid glycoprotein, albumin) and anti-inflammatory (IL-10, TGF-β1) molecules as well as adipose-related markers such as leptin, adiponectin, ghrelin, and resistin were measured by magnetic bead-based multiplex-specific immunoassays and biochemical assays. Results BC characteristics were different in elderly women and men, and more favorable BC markers were associated with a better adipose-related inflammatory profile, with the exception of skeletal muscle mass index. No correlation was found with the body composition markers and circulating levels of some standard pro- and anti-inflammatory markers like IL-6, pentraxin 3, IL-10, TGF-β1, TNF-α, IL-6Rα, glycoprotein 130, TNF-α-R1, and TNF-α-R2.Conclusions The association between BC and inflammatory and adipose-related biomarkers is crucial in decoding aging and pathophysiological processes, such as sarcopenia. DXA can help in understanding how the measurement of fat and muscle is important, making the way from research to clinical practice.

U2 - 10.1007/s00330-018-5973-2

DO - 10.1007/s00330-018-5973-2

M3 - Article

VL - 29

SP - 4968

EP - 4979

JO - European Radiology

T2 - European Radiology

JF - European Radiology

SN - 0938-7994

IS - 9

ER -