TY - JOUR
T1 - Gastric clot formation and digestion of milk proteins in static in vitro infant gastric digestion models representing different ages
AU - Miltenburg, Julie
AU - Bastiaan-Net, Shanna
AU - Hoppenbrouwers, Tamara
AU - Wichers, Harry
AU - Hettinga, Kasper
PY - 2024/1/30
Y1 - 2024/1/30
N2 - Gastric digestion conditions change during infancy from newborn towards more adult digestion conditions, which can change gastric digestion kinetics. However, how these changes in gastric digestion conditions during infancy affect milk protein digestion has not been investigated. Therefore, we aimed to investigate milk protein digestion with static in vitro gastric digestion models representing one-, three- and six-month-old infants. With increasing age, gastric clots and soluble proteins were digested more extensively, which may partly be attributed to the looser gastric clot structure. Larger differences with increasing age were found for heated than unheated milk proteins, which might be caused by the presence of denatured whey proteins. Taken together, these findings show that gastric milk protein digestion increases during infancy. These in vitro gastric digestion models could be used to study how milk protein digestion changes with infant age, which may aid in developing infant formulas for different age stages.
AB - Gastric digestion conditions change during infancy from newborn towards more adult digestion conditions, which can change gastric digestion kinetics. However, how these changes in gastric digestion conditions during infancy affect milk protein digestion has not been investigated. Therefore, we aimed to investigate milk protein digestion with static in vitro gastric digestion models representing one-, three- and six-month-old infants. With increasing age, gastric clots and soluble proteins were digested more extensively, which may partly be attributed to the looser gastric clot structure. Larger differences with increasing age were found for heated than unheated milk proteins, which might be caused by the presence of denatured whey proteins. Taken together, these findings show that gastric milk protein digestion increases during infancy. These in vitro gastric digestion models could be used to study how milk protein digestion changes with infant age, which may aid in developing infant formulas for different age stages.
KW - Gastric clot
KW - In vitro digestion
KW - Infant age
KW - Milk protein
KW - Protein hydrolysis
U2 - 10.1016/j.foodchem.2023.137209
DO - 10.1016/j.foodchem.2023.137209
M3 - Article
C2 - 37643515
AN - SCOPUS:85169050234
SN - 0308-8146
VL - 432
JO - Food Chemistry
JF - Food Chemistry
M1 - 137209
ER -