Fungal transporters involved in secretion of natural toxic compounds and fungicides

M.A. De Waard

Research output: Contribution to journalAbstractAcademic


ATP-Binding Cassette (ABC) and Major Facilitator Superfamily (MFS) transporters are membrane proteins that can transport toxic compounds of exogenous and endogenous origin. Their activity lowers toxin concentrations in cell compartments and provides protection against such compounds. In plant pathogens, the transporters can play a role in virulence by providing protection against plant defense compounds and secretion of host-specific and non-hostspecific toxins. Transporter activity can also affect fungicide sensitivity. We characterised multiple transporter genes from the saprophytic fungus Aspergillus nidulans, and the plant pathogens Botrytis cinerea and Mycosphaerella graminicola and analysed their function in fungicide sensitivity and virulence on host plants. Deletion mutants of particular ABC transporter genes from B. cinerea and M. graminicola indeed had a decreased virulence. Studies with deletion and overexpression mutants indicated that various genes are involved in sensitivity to modern fungicides and natural toxic products, suggesting that ABC and MFS transporters do play a role in multidrug resistance
Original languageEnglish
Pages (from-to)S161
Issue number6 Suppl.
Publication statusPublished - 2001

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