Functional analysis of SOBIR1 in CLV2-mediated development and defence

Jinbin Wu, Guodong Wang, M.H.A.J. Joosten

Research output: Chapter in Book/Report/Conference proceedingAbstract

Abstract

Receptor-like proteins (RLPs) and receptor-like kinases (RLKs) are cell surface receptors that are essential for detecting invading pathogens and subsequent activation of plant defence responses. In contrast to RLKs, RLPs lack a cytoplasmic kinase domain to trigger downstream signalling leading to host resistance. The RLK SOBIR1 constitutively interacts with Cf-4 and is required for Cf-4-mediated resistance to Cladosporium fulvum [1]. Accumulating evidence shows that SOBIR1 is broadly required for RLP-involved resistance to fungal, oomycete and bacterial pathogens [2, 3]. CLAVATA2 (CLV2) was firstly identified as an RLP in regulating meristem homeostasis in Arabidopsis, tomato and maize [4, 5, 6]. Recent evidence shows that CLV2 also functions in plant-parasitic infection as colonisation by nematodes is reduced in Atclv2 mutants [7] and such mutants are also more resistant to the bacterial pathogen Ralstonia solanacearum [8]. In addition, a pseudo-kinase CORYNE (CRN) interacts with CLV2 and participates in all CLV2-mediated signalling pathways [7, 8, 9]. As the kinase domain of CRN is inactive, the current hypothesis is that the CLV2/CRN heterodimer likely functions together with an unknown RLK [10, 11]. Our preliminary data show that both Arabidopsis and tomato SOBIR1 interact with CLV2, indicating that SOBIR1 might be a good candidate for functionally participating in the CLV2/CRN complex. Further studies will be focused on a possible interaction between SOBIR1 and CRN and the possible involvement of SOBIR1 and the CLV2/CRN heterodimer in the same signalling pathway, including the CLV2/CRN-mediated regulation of stem cell maintenance, susceptibility to nematodes, resistance to R. solanacearum, and the requirement of SOBIR1 for resistance to different pathogens.
Original languageEnglish
Title of host publicationAbstract Book 5th International Conference on Biotic Plant Interaction, Xiamen, China 17-21 August 2017
Pages340-341
Publication statusPublished - 2017

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