Function of the opioid system during inflammation in carp

B.M.L. Verburg-van Kemenade, H.F.J. Savelkoul, M.K. Chadzinska

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

9 Citations (Scopus)


The opioid system is involved in modulation of both innate and acquired immune responses, thus altering resistance to a variety of infectious agents. We sequenced and characterized carp opioid receptors (MOR, DOR, and KOR) and found their regulated expression in piscine leukocytes. Moreover, both in vivo and in vitro opioids affect activity of leukocytes and expression of inflammatory molecules, especially chemokines and chemokine receptors. Our data indicate an evolutionary conserved role for the opioid system in immune regulation
Original languageEnglish
Title of host publicationTrends in Comparative Endocrinology and Neurobiology
EditorsH. Vaudry, E.W. Roubos, G. Coast, M. Vallarino
Place of Publication[S.l.]
ISBN (Print)9781573316712
Publication statusPublished - 2009


  • beta-endorphin
  • in-vitro
  • fish
  • receptors
  • modulation
  • leukocytes
  • innate

Fingerprint Dive into the research topics of 'Function of the opioid system during inflammation in carp'. Together they form a unique fingerprint.

Cite this