TY - JOUR
T1 - Function and regulation of the Na+-Ca2+ exchanger NCX3 splice variants in brain and skeletal muscle
AU - Michel, Lauriane Y.M.
AU - Verkaart, Sjoerd
AU - Koopman, Werner J.H.
AU - Willems, Peter H.G.M.
AU - Hoenderop, Joost G.J.
AU - Bindels, René J.M.
PY - 2014/4/18
Y1 - 2014/4/18
N2 - Background: The Na+-Ca2+ exchanger isoform 3 (NCX3) participates in maintaining calcium homeostasis in brain and skeletal muscle. Results: The two splice variants of NCX3 have distinct regulation and capacity of exchange. Conclusion: Distinct calcium uptake capacity of muscle NCX3 suggests a novel function in muscle exercise physiology. Significance: This study brings a new understanding of the role of NCX3 variants in excitable tissues.
AB - Background: The Na+-Ca2+ exchanger isoform 3 (NCX3) participates in maintaining calcium homeostasis in brain and skeletal muscle. Results: The two splice variants of NCX3 have distinct regulation and capacity of exchange. Conclusion: Distinct calcium uptake capacity of muscle NCX3 suggests a novel function in muscle exercise physiology. Significance: This study brings a new understanding of the role of NCX3 variants in excitable tissues.
U2 - 10.1074/jbc.M113.529388
DO - 10.1074/jbc.M113.529388
M3 - Article
C2 - 24616101
AN - SCOPUS:84898951518
SN - 0021-9258
VL - 289
SP - 11293
EP - 11303
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 16
ER -