Fructose intake is a predictor of LDL particle size in overweight schoolchildren

I. Aeberli, M.B. Zimmermann, L. Molinari, R. Lehmann, D. l'Allemand, G.A. Spinas, K. Berneis

Research output: Contribution to journalArticleAcademicpeer-review

66 Citations (Scopus)

Abstract

Background: High amounts of dietary fructose may contribute to dyslipidemia in adults, but there are few data in children. Childhood adiposity is associated with smaller LDL particle size, but the dietary predictors of LDL size in overweight children have not been studied. Objectives: We aimed to determine whether LDL particle size is associated with dietary factors and specifically with fructose intake in normal-weight and overweight children. Design: In a cross-sectional study of normal-weight and overweight 6¿14 y-old Swiss children (n = 74), dietary intakes were assessed by using two 24-h-recalls and a 1-d dietary record. Body mass index (BMI) and waist-hip ratio (WHR) were measured, and plasma lipid profile and LDL particle size were determined. Results: Compared with the normal-weight group, overweight children had significantly higher plasma triacylglycerol concentrations, lower HDL-cholesterol concentrations, and smaller LDL particle size (P <0.05). LDL particle size was inversely correlated to BMI SD scores and WHR (P = 0.007). Although there were no significant differences in total fructose intake, the overweight children consumed a significantly (P <0.05) higher percentage of fructose from sweets and sweetened drinks than did the normal-weight children. After control for adiposity, the only dietary factor that was a significant predictor of LDL particle size was total fructose intake (P = 0.024). Conclusions: In school-age children, greater total and central adiposity are associated with smaller LDL particle size and lower HDL cholesterol. Overweight children consume more fructose from sweets and sweetened drinks than do normal-weight children, and higher fructose intake predicts smaller LDL particle size
Original languageEnglish
Pages (from-to)1174-1178
JournalAmerican Journal of Clinical Nutrition
Volume86
Issue number4
DOIs
Publication statusPublished - 2007

Fingerprint

Fructose
Particle Size
Adiposity
Weights and Measures
Waist-Hip Ratio
HDL Cholesterol
Body Mass Index
oxidized low density lipoprotein
Diet Records
Dyslipidemias
Triglycerides
Cross-Sectional Studies
Lipids

Keywords

  • insulin-resistance syndrome
  • low-density lipoproteins
  • for-disease-control
  • low-fat diet
  • subclass patterns
  • swiss children
  • plasma-lipids
  • men
  • obesity
  • adolescents

Cite this

Aeberli, I., Zimmermann, M. B., Molinari, L., Lehmann, R., l'Allemand, D., Spinas, G. A., & Berneis, K. (2007). Fructose intake is a predictor of LDL particle size in overweight schoolchildren. American Journal of Clinical Nutrition, 86(4), 1174-1178. https://doi.org/10.1093/ajcn/86.4.1174
Aeberli, I. ; Zimmermann, M.B. ; Molinari, L. ; Lehmann, R. ; l'Allemand, D. ; Spinas, G.A. ; Berneis, K. / Fructose intake is a predictor of LDL particle size in overweight schoolchildren. In: American Journal of Clinical Nutrition. 2007 ; Vol. 86, No. 4. pp. 1174-1178.
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abstract = "Background: High amounts of dietary fructose may contribute to dyslipidemia in adults, but there are few data in children. Childhood adiposity is associated with smaller LDL particle size, but the dietary predictors of LDL size in overweight children have not been studied. Objectives: We aimed to determine whether LDL particle size is associated with dietary factors and specifically with fructose intake in normal-weight and overweight children. Design: In a cross-sectional study of normal-weight and overweight 6¿14 y-old Swiss children (n = 74), dietary intakes were assessed by using two 24-h-recalls and a 1-d dietary record. Body mass index (BMI) and waist-hip ratio (WHR) were measured, and plasma lipid profile and LDL particle size were determined. Results: Compared with the normal-weight group, overweight children had significantly higher plasma triacylglycerol concentrations, lower HDL-cholesterol concentrations, and smaller LDL particle size (P <0.05). LDL particle size was inversely correlated to BMI SD scores and WHR (P = 0.007). Although there were no significant differences in total fructose intake, the overweight children consumed a significantly (P <0.05) higher percentage of fructose from sweets and sweetened drinks than did the normal-weight children. After control for adiposity, the only dietary factor that was a significant predictor of LDL particle size was total fructose intake (P = 0.024). Conclusions: In school-age children, greater total and central adiposity are associated with smaller LDL particle size and lower HDL cholesterol. Overweight children consume more fructose from sweets and sweetened drinks than do normal-weight children, and higher fructose intake predicts smaller LDL particle size",
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Aeberli, I, Zimmermann, MB, Molinari, L, Lehmann, R, l'Allemand, D, Spinas, GA & Berneis, K 2007, 'Fructose intake is a predictor of LDL particle size in overweight schoolchildren', American Journal of Clinical Nutrition, vol. 86, no. 4, pp. 1174-1178. https://doi.org/10.1093/ajcn/86.4.1174

Fructose intake is a predictor of LDL particle size in overweight schoolchildren. / Aeberli, I.; Zimmermann, M.B.; Molinari, L.; Lehmann, R.; l'Allemand, D.; Spinas, G.A.; Berneis, K.

In: American Journal of Clinical Nutrition, Vol. 86, No. 4, 2007, p. 1174-1178.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Fructose intake is a predictor of LDL particle size in overweight schoolchildren

AU - Aeberli, I.

AU - Zimmermann, M.B.

AU - Molinari, L.

AU - Lehmann, R.

AU - l'Allemand, D.

AU - Spinas, G.A.

AU - Berneis, K.

PY - 2007

Y1 - 2007

N2 - Background: High amounts of dietary fructose may contribute to dyslipidemia in adults, but there are few data in children. Childhood adiposity is associated with smaller LDL particle size, but the dietary predictors of LDL size in overweight children have not been studied. Objectives: We aimed to determine whether LDL particle size is associated with dietary factors and specifically with fructose intake in normal-weight and overweight children. Design: In a cross-sectional study of normal-weight and overweight 6¿14 y-old Swiss children (n = 74), dietary intakes were assessed by using two 24-h-recalls and a 1-d dietary record. Body mass index (BMI) and waist-hip ratio (WHR) were measured, and plasma lipid profile and LDL particle size were determined. Results: Compared with the normal-weight group, overweight children had significantly higher plasma triacylglycerol concentrations, lower HDL-cholesterol concentrations, and smaller LDL particle size (P <0.05). LDL particle size was inversely correlated to BMI SD scores and WHR (P = 0.007). Although there were no significant differences in total fructose intake, the overweight children consumed a significantly (P <0.05) higher percentage of fructose from sweets and sweetened drinks than did the normal-weight children. After control for adiposity, the only dietary factor that was a significant predictor of LDL particle size was total fructose intake (P = 0.024). Conclusions: In school-age children, greater total and central adiposity are associated with smaller LDL particle size and lower HDL cholesterol. Overweight children consume more fructose from sweets and sweetened drinks than do normal-weight children, and higher fructose intake predicts smaller LDL particle size

AB - Background: High amounts of dietary fructose may contribute to dyslipidemia in adults, but there are few data in children. Childhood adiposity is associated with smaller LDL particle size, but the dietary predictors of LDL size in overweight children have not been studied. Objectives: We aimed to determine whether LDL particle size is associated with dietary factors and specifically with fructose intake in normal-weight and overweight children. Design: In a cross-sectional study of normal-weight and overweight 6¿14 y-old Swiss children (n = 74), dietary intakes were assessed by using two 24-h-recalls and a 1-d dietary record. Body mass index (BMI) and waist-hip ratio (WHR) were measured, and plasma lipid profile and LDL particle size were determined. Results: Compared with the normal-weight group, overweight children had significantly higher plasma triacylglycerol concentrations, lower HDL-cholesterol concentrations, and smaller LDL particle size (P <0.05). LDL particle size was inversely correlated to BMI SD scores and WHR (P = 0.007). Although there were no significant differences in total fructose intake, the overweight children consumed a significantly (P <0.05) higher percentage of fructose from sweets and sweetened drinks than did the normal-weight children. After control for adiposity, the only dietary factor that was a significant predictor of LDL particle size was total fructose intake (P = 0.024). Conclusions: In school-age children, greater total and central adiposity are associated with smaller LDL particle size and lower HDL cholesterol. Overweight children consume more fructose from sweets and sweetened drinks than do normal-weight children, and higher fructose intake predicts smaller LDL particle size

KW - insulin-resistance syndrome

KW - low-density lipoproteins

KW - for-disease-control

KW - low-fat diet

KW - subclass patterns

KW - swiss children

KW - plasma-lipids

KW - men

KW - obesity

KW - adolescents

U2 - 10.1093/ajcn/86.4.1174

DO - 10.1093/ajcn/86.4.1174

M3 - Article

VL - 86

SP - 1174

EP - 1178

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 4

ER -

Aeberli I, Zimmermann MB, Molinari L, Lehmann R, l'Allemand D, Spinas GA et al. Fructose intake is a predictor of LDL particle size in overweight schoolchildren. American Journal of Clinical Nutrition. 2007;86(4):1174-1178. https://doi.org/10.1093/ajcn/86.4.1174