From nucleosome to chromosome: a dynamic organization of genetic information

P.F. Fransz; J.H.S.G.M. de Jong

doi:10.1111/j.1365-313X.2011.04526.x

From nucleosome to chromosome: a dynamic organization of genetic information

P.F. Fransz, J.H.S.G.M. de Jong

Research output: Contribution to journal › Article › Academic › peer-review

79 Citations (Scopus)

Abstract

Gene activity is controlled at different levels of chromatin organization, which involve genomic sequences, nucleosome structure, chromatin folding and chromosome arrangement. These levels are interconnected and influence each other. At the basic level nucleosomes generally occlude the DNA sequence from interacting with DNA-binding proteins. Evidently, nucleosome positioning is a major factor in gene control and chromatin organization. Understanding the biological rules that govern the deposition and removal of the nucleosomes to and from the chromatin fiber is the key to understanding gene regulation and chromatin organization. In this review we describe and discuss the relationship between the different levels of chromatin organization in plants and animals

Original language	English
Pages (from-to)	4-17
Journal	The Plant Journal
Volume	66
Issue number	1
DOIs	https://doi.org/10.1111/j.1365-313X.2011.04526.x
Publication status	Published - 2011

Keywords

histone variant h2a.z
30-nm chromatin fiber
arabidopsis-thaliana
dna methylation
interphase chromosomes
in-vivo
nuclear architecture
insitu hybridization
regulatory regions
h4-k16 acetylation

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10.1111/j.1365-313X.2011.04526.x

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title = "From nucleosome to chromosome: a dynamic organization of genetic information",

abstract = "Gene activity is controlled at different levels of chromatin organization, which involve genomic sequences, nucleosome structure, chromatin folding and chromosome arrangement. These levels are interconnected and influence each other. At the basic level nucleosomes generally occlude the DNA sequence from interacting with DNA-binding proteins. Evidently, nucleosome positioning is a major factor in gene control and chromatin organization. Understanding the biological rules that govern the deposition and removal of the nucleosomes to and from the chromatin fiber is the key to understanding gene regulation and chromatin organization. In this review we describe and discuss the relationship between the different levels of chromatin organization in plants and animals",

keywords = "histone variant h2a.z, 30-nm chromatin fiber, arabidopsis-thaliana, dna methylation, interphase chromosomes, in-vivo, nuclear architecture, insitu hybridization, regulatory regions, h4-k16 acetylation",

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AU - de Jong, J.H.S.G.M.

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AB - Gene activity is controlled at different levels of chromatin organization, which involve genomic sequences, nucleosome structure, chromatin folding and chromosome arrangement. These levels are interconnected and influence each other. At the basic level nucleosomes generally occlude the DNA sequence from interacting with DNA-binding proteins. Evidently, nucleosome positioning is a major factor in gene control and chromatin organization. Understanding the biological rules that govern the deposition and removal of the nucleosomes to and from the chromatin fiber is the key to understanding gene regulation and chromatin organization. In this review we describe and discuss the relationship between the different levels of chromatin organization in plants and animals

KW - histone variant h2a.z

KW - 30-nm chromatin fiber

KW - arabidopsis-thaliana

KW - dna methylation

KW - interphase chromosomes

KW - in-vivo

KW - nuclear architecture

KW - insitu hybridization

KW - regulatory regions

KW - h4-k16 acetylation

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DO - 10.1111/j.1365-313X.2011.04526.x

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VL - 66

SP - 4

EP - 17

JO - The Plant Journal

JF - The Plant Journal

IS - 1

ER -

From nucleosome to chromosome: a dynamic organization of genetic information

Abstract

Keywords

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