Freedom of expression: A synthetic route to metabolites

Hannah E. Augustijn; Marnix H. Medema

doi:10.1016/j.cell.2022.04.007

Freedom of expression: A synthetic route to metabolites

Hannah E. Augustijn, Marnix H. Medema^*

^*Corresponding author for this work

Bioinformatics

Research output: Contribution to journal › Comment/Letter to the editor › Academic

1 Citation (Scopus)

Abstract

Microbial specialized metabolites play key roles in microbiome interactions, but their biosynthetic pathways are difficult to characterize. In this issue, Patel et al. (2022) describe new technologies for the computer-aided redesign of gene clusters to facilitate heterologous expression across diverse hosts and showcase their utility by identifying a new class of microbiome-derived nucleotide metabolites.

Original language	English
Pages (from-to)	1449-1451
Journal	Cell
Volume	185
Issue number	9
DOIs	https://doi.org/10.1016/j.cell.2022.04.007
Publication status	Published - 28 Apr 2022

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title = "Freedom of expression: A synthetic route to metabolites",

abstract = "Microbial specialized metabolites play key roles in microbiome interactions, but their biosynthetic pathways are difficult to characterize. In this issue, Patel et al. (2022) describe new technologies for the computer-aided redesign of gene clusters to facilitate heterologous expression across diverse hosts and showcase their utility by identifying a new class of microbiome-derived nucleotide metabolites.",

author = "Augustijn, {Hannah E.} and Medema, {Marnix H.}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

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T1 - Freedom of expression

T2 - A synthetic route to metabolites

AU - Augustijn, Hannah E.

AU - Medema, Marnix H.

PY - 2022/4/28

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N2 - Microbial specialized metabolites play key roles in microbiome interactions, but their biosynthetic pathways are difficult to characterize. In this issue, Patel et al. (2022) describe new technologies for the computer-aided redesign of gene clusters to facilitate heterologous expression across diverse hosts and showcase their utility by identifying a new class of microbiome-derived nucleotide metabolites.

AB - Microbial specialized metabolites play key roles in microbiome interactions, but their biosynthetic pathways are difficult to characterize. In this issue, Patel et al. (2022) describe new technologies for the computer-aided redesign of gene clusters to facilitate heterologous expression across diverse hosts and showcase their utility by identifying a new class of microbiome-derived nucleotide metabolites.

U2 - 10.1016/j.cell.2022.04.007

DO - 10.1016/j.cell.2022.04.007

M3 - Comment/Letter to the editor

C2 - 35487188

AN - SCOPUS:85129135063

VL - 185

SP - 1449

EP - 1451

JO - Cell

JF - Cell

SN - 0092-8674

IS - 9

ER -

Freedom of expression: A synthetic route to metabolites

Abstract

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