Fosfomycin susceptibility of canine methicillin-resistant Staphylococcus pseudintermedius isolates

Matthew DiCicco; Scott Weese; Suresh Neethirajan; Joyce Rousseau; Ameet Singh

doi:10.1016/j.rvsc.2014.02.004

Fosfomycin susceptibility of canine methicillin-resistant Staphylococcus pseudintermedius isolates

Matthew DiCicco, Scott Weese, Suresh Neethirajan^*, Joyce Rousseau, Ameet Singh

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

13 Citations (Scopus)

Abstract

The effectiveness of fosfomycin was examined across 31 methicillin-resistant Staphylococcus pseudintermedius (MRSP) strains by agar dilution. Prevalence of the fosfomycin-resistance determinant gene, fosB, was assessed by PCR analysis. Results found that 84% of isolates were fosfomycin-susceptible. Interestingly, 87% of isolates possessed fosB, indicating no association between this putative staphylococci resistance gene and phenotypic resistance. Further evaluation of fosfomycin as a potential treatment of MRSP in dogs is warranted.

Original language	English
Pages (from-to)	251-253
Number of pages	3
Journal	Research in Veterinary Science
Volume	96
Issue number	2
DOIs	https://doi.org/10.1016/j.rvsc.2014.02.004
Publication status	Published - Apr 2014
Externally published	Yes

Keywords

FosB
Fosfomycin
Methicillin-resistant
MRSP
Staphylococcus pseudintermedius

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10.1016/j.rvsc.2014.02.004

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title = "Fosfomycin susceptibility of canine methicillin-resistant Staphylococcus pseudintermedius isolates",

abstract = "The effectiveness of fosfomycin was examined across 31 methicillin-resistant Staphylococcus pseudintermedius (MRSP) strains by agar dilution. Prevalence of the fosfomycin-resistance determinant gene, fosB, was assessed by PCR analysis. Results found that 84% of isolates were fosfomycin-susceptible. Interestingly, 87% of isolates possessed fosB, indicating no association between this putative staphylococci resistance gene and phenotypic resistance. Further evaluation of fosfomycin as a potential treatment of MRSP in dogs is warranted.",

keywords = "FosB, Fosfomycin, Methicillin-resistant, MRSP, Staphylococcus pseudintermedius",

author = "Matthew DiCicco and Scott Weese and Suresh Neethirajan and Joyce Rousseau and Ameet Singh",

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doi = "10.1016/j.rvsc.2014.02.004",

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T1 - Fosfomycin susceptibility of canine methicillin-resistant Staphylococcus pseudintermedius isolates

AU - DiCicco, Matthew

AU - Weese, Scott

AU - Neethirajan, Suresh

AU - Rousseau, Joyce

AU - Singh, Ameet

PY - 2014/4

Y1 - 2014/4

N2 - The effectiveness of fosfomycin was examined across 31 methicillin-resistant Staphylococcus pseudintermedius (MRSP) strains by agar dilution. Prevalence of the fosfomycin-resistance determinant gene, fosB, was assessed by PCR analysis. Results found that 84% of isolates were fosfomycin-susceptible. Interestingly, 87% of isolates possessed fosB, indicating no association between this putative staphylococci resistance gene and phenotypic resistance. Further evaluation of fosfomycin as a potential treatment of MRSP in dogs is warranted.

AB - The effectiveness of fosfomycin was examined across 31 methicillin-resistant Staphylococcus pseudintermedius (MRSP) strains by agar dilution. Prevalence of the fosfomycin-resistance determinant gene, fosB, was assessed by PCR analysis. Results found that 84% of isolates were fosfomycin-susceptible. Interestingly, 87% of isolates possessed fosB, indicating no association between this putative staphylococci resistance gene and phenotypic resistance. Further evaluation of fosfomycin as a potential treatment of MRSP in dogs is warranted.

KW - FosB

KW - Fosfomycin

KW - Methicillin-resistant

KW - MRSP

KW - Staphylococcus pseudintermedius

U2 - 10.1016/j.rvsc.2014.02.004

DO - 10.1016/j.rvsc.2014.02.004

M3 - Article

C2 - 24569298

AN - SCOPUS:84896494455

SN - 0034-5288

VL - 96

SP - 251

EP - 253

JO - Research in Veterinary Science

JF - Research in Veterinary Science

IS - 2

ER -

Fosfomycin susceptibility of canine methicillin-resistant Staphylococcus pseudintermedius isolates

Abstract

Keywords

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