Foot-and-mouth disease virus : the role of infection routes and species differences in the transmission of FMDV

C. Bravo De Rueda Cabrera

Research output: Thesisinternal PhD, WU

Abstract

ÁFoot-and-mouth disease is a contagious viral disease of cloven-hoofed animals (e.g. cattle, sheep, pigs) and can cause severe economic losses to the farm animal industries. The aim of this thesis was to quantify underlying mechanisms regarding transmission of FMDV. With data from past animal experiments we identified the factors which are associated with the amount of virus shed by infected animals and thus may be of importance for transmission of the virus.  In an experimental study, the contribution of the environment on the transmission of FMDV was investigated by using a new mathematical model in which the contribution of the environment on transmission was incorporated. Roughly 44% of the transmission of FMDV occurred through the environment that was contaminated with se-excretions from FMDV infected animals.  The role of the different species on the transmission of FMDV was investigated with a transmission study of FMDV between infected sheep and naïve cattle. Sheep were found to be less infectious than cattle but similarly susceptible.  Using a so-called next-generation matrix, transmission of FMDV in mixed cattle-sheep populations (with different proportions of cattle and different proportions of vaccinated animals) was quantified and the effects of different vaccination strategies against FMDV were analysed. In mixed populations of cattle and sheep, transmission of FMDV is higher when more cattle are present. In populations with more than 14% cattle, targeting vaccination to cattle only can be sufficient to control FMDV.

The results of this thesis show that transmission of FMDV can occur via a contaminated environment, (without animal presence) and that sheep seem to play a limited role in the transmission of FMDV. These results can be used to improve the control measures to prevent and control FMDV in different animal populations.

 

 

Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Wageningen University
Supervisors/Advisors
  • de Jong, Mart, Promotor
  • Dekker, Aldo, Co-promotor
  • Eble, Phaedra, Co-promotor
Award date1 Jun 2015
Place of PublicationWageningen
Publisher
Print ISBNs9789462573284
Publication statusPublished - 2015

Fingerprint

Foot-and-mouth disease virus
interspecific variation
cattle
infection
sheep
animals
vaccination
animal experimentation
sheds
virus transmission
foot-and-mouth disease
farmed animal species
control methods
mathematical models
excretion
industry
economics
viruses
swine

Keywords

  • foot-and-mouth disease virus
  • foot and mouth disease
  • infectious diseases
  • disease transmission
  • disease control
  • infection control
  • species differences
  • epidemiology
  • veterinary science

Cite this

Bravo De Rueda Cabrera, C.. / Foot-and-mouth disease virus : the role of infection routes and species differences in the transmission of FMDV. Wageningen : Wageningen University, 2015. 137 p.
@phdthesis{e8bd406207e1499c989dc076cc9963a6,
title = "Foot-and-mouth disease virus : the role of infection routes and species differences in the transmission of FMDV",
abstract = "{\'A}Foot-and-mouth disease is a contagious viral disease of cloven-hoofed animals (e.g. cattle, sheep, pigs) and can cause severe economic losses to the farm animal industries. The aim of this thesis was to quantify underlying mechanisms regarding transmission of FMDV. With data from past animal experiments we identified the factors which are associated with the amount of virus shed by infected animals and thus may be of importance for transmission of the virus.  In an experimental study, the contribution of the environment on the transmission of FMDV was investigated by using a new mathematical model in which the contribution of the environment on transmission was incorporated. Roughly 44{\%} of the transmission of FMDV occurred through the environment that was contaminated with se-excretions from FMDV infected animals.  The role of the different species on the transmission of FMDV was investigated with a transmission study of FMDV between infected sheep and na{\"i}ve cattle. Sheep were found to be less infectious than cattle but similarly susceptible.  Using a so-called next-generation matrix, transmission of FMDV in mixed cattle-sheep populations (with different proportions of cattle and different proportions of vaccinated animals) was quantified and the effects of different vaccination strategies against FMDV were analysed. In mixed populations of cattle and sheep, transmission of FMDV is higher when more cattle are present. In populations with more than 14{\%} cattle, targeting vaccination to cattle only can be sufficient to control FMDV. The results of this thesis show that transmission of FMDV can occur via a contaminated environment, (without animal presence) and that sheep seem to play a limited role in the transmission of FMDV. These results can be used to improve the control measures to prevent and control FMDV in different animal populations.    ",
keywords = "mond- en klauwzeervirus, mond- en klauwzeer, infectieziekten, ziekteoverdracht, ziektebestrijding, infectiebestrijding, soortverschillen, epidemiologie, diergeneeskunde, foot-and-mouth disease virus, foot and mouth disease, infectious diseases, disease transmission, disease control, infection control, species differences, epidemiology, veterinary science",
author = "{Bravo De Rueda Cabrera}, C.",
note = "WU thesis 6045",
year = "2015",
language = "English",
isbn = "9789462573284",
publisher = "Wageningen University",
school = "Wageningen University",

}

Bravo De Rueda Cabrera, C 2015, 'Foot-and-mouth disease virus : the role of infection routes and species differences in the transmission of FMDV', Doctor of Philosophy, Wageningen University, Wageningen.

Foot-and-mouth disease virus : the role of infection routes and species differences in the transmission of FMDV. / Bravo De Rueda Cabrera, C.

Wageningen : Wageningen University, 2015. 137 p.

Research output: Thesisinternal PhD, WU

TY - THES

T1 - Foot-and-mouth disease virus : the role of infection routes and species differences in the transmission of FMDV

AU - Bravo De Rueda Cabrera, C.

N1 - WU thesis 6045

PY - 2015

Y1 - 2015

N2 - ÁFoot-and-mouth disease is a contagious viral disease of cloven-hoofed animals (e.g. cattle, sheep, pigs) and can cause severe economic losses to the farm animal industries. The aim of this thesis was to quantify underlying mechanisms regarding transmission of FMDV. With data from past animal experiments we identified the factors which are associated with the amount of virus shed by infected animals and thus may be of importance for transmission of the virus.  In an experimental study, the contribution of the environment on the transmission of FMDV was investigated by using a new mathematical model in which the contribution of the environment on transmission was incorporated. Roughly 44% of the transmission of FMDV occurred through the environment that was contaminated with se-excretions from FMDV infected animals.  The role of the different species on the transmission of FMDV was investigated with a transmission study of FMDV between infected sheep and naïve cattle. Sheep were found to be less infectious than cattle but similarly susceptible.  Using a so-called next-generation matrix, transmission of FMDV in mixed cattle-sheep populations (with different proportions of cattle and different proportions of vaccinated animals) was quantified and the effects of different vaccination strategies against FMDV were analysed. In mixed populations of cattle and sheep, transmission of FMDV is higher when more cattle are present. In populations with more than 14% cattle, targeting vaccination to cattle only can be sufficient to control FMDV. The results of this thesis show that transmission of FMDV can occur via a contaminated environment, (without animal presence) and that sheep seem to play a limited role in the transmission of FMDV. These results can be used to improve the control measures to prevent and control FMDV in different animal populations.    

AB - ÁFoot-and-mouth disease is a contagious viral disease of cloven-hoofed animals (e.g. cattle, sheep, pigs) and can cause severe economic losses to the farm animal industries. The aim of this thesis was to quantify underlying mechanisms regarding transmission of FMDV. With data from past animal experiments we identified the factors which are associated with the amount of virus shed by infected animals and thus may be of importance for transmission of the virus.  In an experimental study, the contribution of the environment on the transmission of FMDV was investigated by using a new mathematical model in which the contribution of the environment on transmission was incorporated. Roughly 44% of the transmission of FMDV occurred through the environment that was contaminated with se-excretions from FMDV infected animals.  The role of the different species on the transmission of FMDV was investigated with a transmission study of FMDV between infected sheep and naïve cattle. Sheep were found to be less infectious than cattle but similarly susceptible.  Using a so-called next-generation matrix, transmission of FMDV in mixed cattle-sheep populations (with different proportions of cattle and different proportions of vaccinated animals) was quantified and the effects of different vaccination strategies against FMDV were analysed. In mixed populations of cattle and sheep, transmission of FMDV is higher when more cattle are present. In populations with more than 14% cattle, targeting vaccination to cattle only can be sufficient to control FMDV. The results of this thesis show that transmission of FMDV can occur via a contaminated environment, (without animal presence) and that sheep seem to play a limited role in the transmission of FMDV. These results can be used to improve the control measures to prevent and control FMDV in different animal populations.    

KW - mond- en klauwzeervirus

KW - mond- en klauwzeer

KW - infectieziekten

KW - ziekteoverdracht

KW - ziektebestrijding

KW - infectiebestrijding

KW - soortverschillen

KW - epidemiologie

KW - diergeneeskunde

KW - foot-and-mouth disease virus

KW - foot and mouth disease

KW - infectious diseases

KW - disease transmission

KW - disease control

KW - infection control

KW - species differences

KW - epidemiology

KW - veterinary science

M3 - internal PhD, WU

SN - 9789462573284

PB - Wageningen University

CY - Wageningen

ER -

Bravo De Rueda Cabrera C. Foot-and-mouth disease virus : the role of infection routes and species differences in the transmission of FMDV. Wageningen: Wageningen University, 2015. 137 p.