Food resource allocation patterns in lactating females in a long-term selection experiment for litter size in mice

W.M. Rauw, P.W. Knap, M.W.A. Verstegen, P. Luiting

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Abstract

Resource allocation patterns, as quantified by residual food intake (RFI), and the consequences for offspring development were investigated during lactation in 96 females of a mouse line selected for 104 generations for high litter size at birth (S-line) and in 87 females of a non-selected control line (C-line). Litters of 45 C-line dams (Cs) and 48 S-line dams (Ss) were standardised (s) at birth; other dams (ns) supported total number of pups born (Cns and Sns, respectively). RFI during lactation was significantly lower in Sns-dams than in C-line dams and Sns-dams. After weaning Sns-dams seemed to be able to restore the negative resource situation. Sns-pups were about 25␕ess mature than Cns-pups at all times. Maturity was similar for Cs- and Ss-pups from 2 d in lactation on, and about 18nd 53␑igher than Cns- and Sns-pups. The pre-weaning mortality rate was significantly higher in Sns-litters ( ) than in Cns-litters ( ). The results suggest that S-line dams allocated considerably more resources to maintenance of offspring than C-line dams. This was insufficient to provide the offspring with an adequate amount of resources, resulting in reduced pup development and increased pre-weaning mortality rates.
Original languageEnglish
Pages (from-to)83-104
JournalGenetics, Selection, Evolution
Volume34
Issue number1
DOIs
Publication statusPublished - 2002

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