Food matrix interaction and bioavailability of bioactive peptides: Two faces of the same coin?

Chibuike C. Udenigwe*, Vincenzo Fogliano

*Corresponding author for this work

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

83 Citations (Scopus)


Several peptides derived from food protein digestion possess regulatory functions that can lead to health promotion. Such peptides can be used as nutraceuticals and their inclusion as active components of functional food products is increasingly gaining attention. However, physiological evidence to support health benefits is available only in some cases. Low bioavailability of peptides is a major factor that limits their application and often attributed to their selective intestinal uptake and physiological instability when consumed orally. Peptides are notably reactive due to their nucleophilic moieties. This makes them highly susceptible to undergoing structural changes and reactions with the food matrix during product development. Such interactions can reduce the bioaccessibility and bioavailability of peptides, and can also alter their biological activities when measured using in vitro assays. Food matrix-peptide interactions can result in the generation of new compounds, which may be bioactive or undesirable. Moving forward, it is important to select friendly processing methods and less reactive matrices when producing peptides to preserve their structures and improve their bioaccessibility, bioavailability and use in products designed for disease prevention and management.
Original languageEnglish
Pages (from-to)9-12
JournalJournal of Functional Foods
Publication statusPublished - 2017


  • Bioaccessibility
  • Bioactive peptides
  • Bioavailability
  • Food matrix
  • Matrix interaction


Dive into the research topics of 'Food matrix interaction and bioavailability of bioactive peptides: Two faces of the same coin?'. Together they form a unique fingerprint.

Cite this