Food and feed safety assessment of RNAi plants and products

H. Naegeli; G.A. Kleter; A. Dietz-Pfeilstetter

doi:10.1079/9781789248890.0013

Food and feed safety assessment of RNAi plants and products

H. Naegeli^*, G.A. Kleter, A. Dietz-Pfeilstetter

^*Corresponding author for this work

Team Bacteriology, Molecular Biology & AMR

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

1 Citation (Scopus)

Abstract

This paper evaluates the potential hazards of food and feed derived from RNAi plants including: adverse changes of plant metabolism; mechanisms and potential for non-target gene silencing in humans and livestock, including gut microbiome; bioinformatics tools for predictionof off-target sequences of interfering RNA; the possible non-specific effects of dsRNA and siRNA in mammals; and the comparison of data requirements for safety assessment of food and feed from RNAi plants and from plants expressing recombinant proteins. It also discusses exposure and RNAi-specific risk assessment.

Original language	English
Title of host publication	RNAi for Plant Improvement and Protection
Editors	B. Mezzetti, J. Sweet, L. Burgos
Place of Publication	Wallingford
Publisher	CABI
Chapter	13
Pages	131-153
ISBN (Print)	9781789248890
DOIs	https://doi.org/10.1079/9781789248890.0013
Publication status	Published - 2021

Keywords

Bioinformatics
Comparisons
Domestic animals
Effects
Epigenetics
Exposure
Feeds
Food
Food safety
Foods
Gene expression
Gene silencing
Genes
Genetic engineering
Intestinal microorganisms
Livestock
Metabolism
Microbial flora
Microorganisms
Molecular genetics
Nucleotide sequences
Plant products
Proteins
Recombinant proteins
Risk
Risk assessment
RNA
RNA interference

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10.1079/9781789248890.0013Licence: CC BY-NC-ND

https://edepot.wur.nl/560759Licence: CC BY-NC-ND

Cite this

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title = "Food and feed safety assessment of RNAi plants and products",

abstract = "This paper evaluates the potential hazards of food and feed derived from RNAi plants including: adverse changes of plant metabolism; mechanisms and potential for non-target gene silencing in humans and livestock, including gut microbiome; bioinformatics tools for predictionof off-target sequences of interfering RNA; the possible non-specific effects of dsRNA and siRNA in mammals; and the comparison of data requirements for safety assessment of food and feed from RNAi plants and from plants expressing recombinant proteins. It also discusses exposure and RNAi-specific risk assessment.",

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author = "H. Naegeli and G.A. Kleter and A. Dietz-Pfeilstetter",

year = "2021",

doi = "10.1079/9781789248890.0013",

language = "English",

isbn = "9781789248890",

pages = "131--153",

editor = "B. Mezzetti and J. Sweet and L. Burgos",

booktitle = "RNAi for Plant Improvement and Protection",

publisher = "CABI",

address = "United Kingdom",

}

TY - CHAP

T1 - Food and feed safety assessment of RNAi plants and products

AU - Naegeli, H.

AU - Kleter, G.A.

AU - Dietz-Pfeilstetter, A.

PY - 2021

Y1 - 2021

N2 - This paper evaluates the potential hazards of food and feed derived from RNAi plants including: adverse changes of plant metabolism; mechanisms and potential for non-target gene silencing in humans and livestock, including gut microbiome; bioinformatics tools for predictionof off-target sequences of interfering RNA; the possible non-specific effects of dsRNA and siRNA in mammals; and the comparison of data requirements for safety assessment of food and feed from RNAi plants and from plants expressing recombinant proteins. It also discusses exposure and RNAi-specific risk assessment.

AB - This paper evaluates the potential hazards of food and feed derived from RNAi plants including: adverse changes of plant metabolism; mechanisms and potential for non-target gene silencing in humans and livestock, including gut microbiome; bioinformatics tools for predictionof off-target sequences of interfering RNA; the possible non-specific effects of dsRNA and siRNA in mammals; and the comparison of data requirements for safety assessment of food and feed from RNAi plants and from plants expressing recombinant proteins. It also discusses exposure and RNAi-specific risk assessment.

KW - Bioinformatics

KW - Comparisons

KW - Domestic animals

KW - Effects

KW - Epigenetics

KW - Exposure

KW - Feeds

KW - Food

KW - Food safety

KW - Foods

KW - Gene expression

KW - Gene silencing

KW - Genes

KW - Genetic engineering

KW - Intestinal microorganisms

KW - Livestock

KW - Metabolism

KW - Microbial flora

KW - Microorganisms

KW - Molecular genetics

KW - Nucleotide sequences

KW - Plant products

KW - Proteins

KW - Recombinant proteins

KW - Risk

KW - Risk assessment

KW - RNA

KW - RNA interference

U2 - 10.1079/9781789248890.0013

DO - 10.1079/9781789248890.0013

M3 - Chapter

SN - 9781789248890

SP - 131

EP - 153

BT - RNAi for Plant Improvement and Protection

A2 - Mezzetti, B.

A2 - Sweet, J.

A2 - Burgos, L.

PB - CABI

CY - Wallingford

ER -

Food and feed safety assessment of RNAi plants and products

Abstract

Keywords

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