Follicle size and reproductive hormone profiles during a post-weaning altrenogest treatment in primiparous sows

J.J.J. van Leeuwen, M.R.T.M. Martens, J. Jourquin, M.A. Draincourt, A. Wagner, B. Kemp, N.M. Soede

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Abstract

This study investigated the endocrine background of follicle size changes during post-weaning altrenogest treatment. altrenogest-treated sows received a 20-mg dosage daily at 8.00 a.m. from Day –1 to Day 14 after weaning. On Day –1, only 3/13 altrenogest-treated sows showed LH pulses compared with 8/8 control sows (P = 0.001). On Day 0, control sows showed a typical high frequency–low amplitude LH pattern, indicative for recruitment of oestrogenic follicles. In altrenogest-treated animals on Day 0, half of the sows showed high frequency–high amplitude pulses from 4–5 h after weaning. In altrenogest-treated sows, average follicle size increased from 3.1 ± 0.5 mm on Day 0 to 4.4 ± 0.6 mm on Day 5, then decreased to 3.7 ± 0.5 mm on Day 7 and stabilised thereafter. FSH and oestradiol (E2) concentrations showed a distinct diurnal pattern; high at 7.00 a.m. and low at 3.00 p.m. E2 concentrations (7.00 a.m.) showed a 2.5-fold increase from Day –1 to Day 2, and subsequently a 2-fold decline to reach a plateau at Day 8. FSH concentrations reached maximum levels by Day 5 and slowly declined afterwards. In conclusion, once-daily administration of altrenogest starting one day before weaning delays the weaning-induced increase in LH pulses. Although FSH and follicle size increase until Day 5 after weaning, follicle E2 production already decreased from Day 2 after weaning. Post-weaning altrenogest treatment thus results in a follicular wave of follicles that lose oestrogenic competence at Day 2 after weaning, presumably related to the changed LH dynamics during altrenogest treatment.
Original languageEnglish
Pages (from-to)304-312
JournalReproduction Fertility and Development
Volume27
Issue number2
DOIs
Publication statusPublished - 2015

Fingerprint

Weaning
sows
weaning
hormones
Hormones
altrenogest
diurnal variation
Mental Competency
estradiol
Estradiol
plateaus
dosage

Keywords

  • litter size
  • luteinizing-hormone
  • allyl trenbolone
  • luteal-phase
  • weaned sows
  • estrus
  • gilts
  • secretion
  • synchronization
  • estradiol

Cite this

van Leeuwen, J.J.J. ; Martens, M.R.T.M. ; Jourquin, J. ; Draincourt, M.A. ; Wagner, A. ; Kemp, B. ; Soede, N.M. / Follicle size and reproductive hormone profiles during a post-weaning altrenogest treatment in primiparous sows. In: Reproduction Fertility and Development. 2015 ; Vol. 27, No. 2. pp. 304-312.
@article{a83c3c8caa9842d797d94bb740df8b22,
title = "Follicle size and reproductive hormone profiles during a post-weaning altrenogest treatment in primiparous sows",
abstract = "This study investigated the endocrine background of follicle size changes during post-weaning altrenogest treatment. altrenogest-treated sows received a 20-mg dosage daily at 8.00 a.m. from Day –1 to Day 14 after weaning. On Day –1, only 3/13 altrenogest-treated sows showed LH pulses compared with 8/8 control sows (P = 0.001). On Day 0, control sows showed a typical high frequency–low amplitude LH pattern, indicative for recruitment of oestrogenic follicles. In altrenogest-treated animals on Day 0, half of the sows showed high frequency–high amplitude pulses from 4–5 h after weaning. In altrenogest-treated sows, average follicle size increased from 3.1 ± 0.5 mm on Day 0 to 4.4 ± 0.6 mm on Day 5, then decreased to 3.7 ± 0.5 mm on Day 7 and stabilised thereafter. FSH and oestradiol (E2) concentrations showed a distinct diurnal pattern; high at 7.00 a.m. and low at 3.00 p.m. E2 concentrations (7.00 a.m.) showed a 2.5-fold increase from Day –1 to Day 2, and subsequently a 2-fold decline to reach a plateau at Day 8. FSH concentrations reached maximum levels by Day 5 and slowly declined afterwards. In conclusion, once-daily administration of altrenogest starting one day before weaning delays the weaning-induced increase in LH pulses. Although FSH and follicle size increase until Day 5 after weaning, follicle E2 production already decreased from Day 2 after weaning. Post-weaning altrenogest treatment thus results in a follicular wave of follicles that lose oestrogenic competence at Day 2 after weaning, presumably related to the changed LH dynamics during altrenogest treatment.",
keywords = "litter size, luteinizing-hormone, allyl trenbolone, luteal-phase, weaned sows, estrus, gilts, secretion, synchronization, estradiol",
author = "{van Leeuwen}, J.J.J. and M.R.T.M. Martens and J. Jourquin and M.A. Draincourt and A. Wagner and B. Kemp and N.M. Soede",
year = "2015",
doi = "10.1071/RD13149",
language = "English",
volume = "27",
pages = "304--312",
journal = "Reproduction Fertility and Development",
issn = "1031-3613",
publisher = "CSIRO Publishing",
number = "2",

}

Follicle size and reproductive hormone profiles during a post-weaning altrenogest treatment in primiparous sows. / van Leeuwen, J.J.J.; Martens, M.R.T.M.; Jourquin, J.; Draincourt, M.A.; Wagner, A.; Kemp, B.; Soede, N.M.

In: Reproduction Fertility and Development, Vol. 27, No. 2, 2015, p. 304-312.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Follicle size and reproductive hormone profiles during a post-weaning altrenogest treatment in primiparous sows

AU - van Leeuwen, J.J.J.

AU - Martens, M.R.T.M.

AU - Jourquin, J.

AU - Draincourt, M.A.

AU - Wagner, A.

AU - Kemp, B.

AU - Soede, N.M.

PY - 2015

Y1 - 2015

N2 - This study investigated the endocrine background of follicle size changes during post-weaning altrenogest treatment. altrenogest-treated sows received a 20-mg dosage daily at 8.00 a.m. from Day –1 to Day 14 after weaning. On Day –1, only 3/13 altrenogest-treated sows showed LH pulses compared with 8/8 control sows (P = 0.001). On Day 0, control sows showed a typical high frequency–low amplitude LH pattern, indicative for recruitment of oestrogenic follicles. In altrenogest-treated animals on Day 0, half of the sows showed high frequency–high amplitude pulses from 4–5 h after weaning. In altrenogest-treated sows, average follicle size increased from 3.1 ± 0.5 mm on Day 0 to 4.4 ± 0.6 mm on Day 5, then decreased to 3.7 ± 0.5 mm on Day 7 and stabilised thereafter. FSH and oestradiol (E2) concentrations showed a distinct diurnal pattern; high at 7.00 a.m. and low at 3.00 p.m. E2 concentrations (7.00 a.m.) showed a 2.5-fold increase from Day –1 to Day 2, and subsequently a 2-fold decline to reach a plateau at Day 8. FSH concentrations reached maximum levels by Day 5 and slowly declined afterwards. In conclusion, once-daily administration of altrenogest starting one day before weaning delays the weaning-induced increase in LH pulses. Although FSH and follicle size increase until Day 5 after weaning, follicle E2 production already decreased from Day 2 after weaning. Post-weaning altrenogest treatment thus results in a follicular wave of follicles that lose oestrogenic competence at Day 2 after weaning, presumably related to the changed LH dynamics during altrenogest treatment.

AB - This study investigated the endocrine background of follicle size changes during post-weaning altrenogest treatment. altrenogest-treated sows received a 20-mg dosage daily at 8.00 a.m. from Day –1 to Day 14 after weaning. On Day –1, only 3/13 altrenogest-treated sows showed LH pulses compared with 8/8 control sows (P = 0.001). On Day 0, control sows showed a typical high frequency–low amplitude LH pattern, indicative for recruitment of oestrogenic follicles. In altrenogest-treated animals on Day 0, half of the sows showed high frequency–high amplitude pulses from 4–5 h after weaning. In altrenogest-treated sows, average follicle size increased from 3.1 ± 0.5 mm on Day 0 to 4.4 ± 0.6 mm on Day 5, then decreased to 3.7 ± 0.5 mm on Day 7 and stabilised thereafter. FSH and oestradiol (E2) concentrations showed a distinct diurnal pattern; high at 7.00 a.m. and low at 3.00 p.m. E2 concentrations (7.00 a.m.) showed a 2.5-fold increase from Day –1 to Day 2, and subsequently a 2-fold decline to reach a plateau at Day 8. FSH concentrations reached maximum levels by Day 5 and slowly declined afterwards. In conclusion, once-daily administration of altrenogest starting one day before weaning delays the weaning-induced increase in LH pulses. Although FSH and follicle size increase until Day 5 after weaning, follicle E2 production already decreased from Day 2 after weaning. Post-weaning altrenogest treatment thus results in a follicular wave of follicles that lose oestrogenic competence at Day 2 after weaning, presumably related to the changed LH dynamics during altrenogest treatment.

KW - litter size

KW - luteinizing-hormone

KW - allyl trenbolone

KW - luteal-phase

KW - weaned sows

KW - estrus

KW - gilts

KW - secretion

KW - synchronization

KW - estradiol

U2 - 10.1071/RD13149

DO - 10.1071/RD13149

M3 - Article

VL - 27

SP - 304

EP - 312

JO - Reproduction Fertility and Development

JF - Reproduction Fertility and Development

SN - 1031-3613

IS - 2

ER -