Flavoenzyme-catalyzed oxygenations and oxidations of phenolic compounds

M.J.H. Moonen, M.W. Fraaije, I.M.C.M. Rietjens, C. Laane, W.J.H. van Berkel

Research output: Contribution to journalArticleAcademicpeer-review

53 Citations (Scopus)


Flavin-dependent monooxygenases and oxidases play an important role in the mineralization of phenolic compounds. Because of their exquisite regioselectivity and stereoselectivity, these enzymes are of interest for the biocatalytic production of fine chemicals and food ingredients. In our group, we have characterized several flavoenzymes that act on phenolic compounds, including 4-hydroxybenzoate 3-hydroxylase, 3-hydroxyphenylacetate 6-hydroxylase, 4-hydroxybenzoate 1-hydroxylase (decarboxylating), hydroquinone hydroxylase, 2-hydroxybiphenyl 3-monooxygenase, phenol hydroxylase, 4-hydroxyacetophenone monooxygenase and vanillyl-alcohol oxidase. The catalytic properties of these enzymes are reviewed here, together with insights obtained from site-directed and random mutagenesis.
Original languageEnglish
Pages (from-to)1023-1035
JournalAdvanced Synthesis and Catalysis
Publication statusPublished - 2002

Fingerprint Dive into the research topics of 'Flavoenzyme-catalyzed oxygenations and oxidations of phenolic compounds'. Together they form a unique fingerprint.

Cite this