Fish oil and omega-3 fatty acids in cardiovascular disease: do they really work?

D. Kromhout, S. Yasuda, J.M. Geleijnse, H. Shimokawa

Research output: Contribution to journalArticleAcademicpeer-review

134 Citations (Scopus)


Omega-3 fatty acids, which are found abundantly in fish oil, exert pleiotropic cardiometabolic effects with a diverse range of actions. The results of previous studies raised a lot of interest in the role of fish oil and omega-3 fatty acids in primary and secondary prevention of cardiovascular diseases. The present review will focus on the current clinical uses of omega-3 fatty acids and provide an update on their effects. Since recently published trials in patients with coronary artery diseases or post-myocardial infarction did not show an effect of omega-3 fatty acids on major cardiovascular endpoints, this review will examine the limitations of those data and suggest recommendations for the use of omega-3 fatty acids
Original languageEnglish
Pages (from-to)436-443
JournalEuropean Heart Journal
Issue number4
Publication statusPublished - 2012


  • coronary-heart-disease
  • polyunsaturated fatty-acids
  • sudden cardiac death
  • placebo-controlled trial
  • endothelium-dependent responses
  • randomized controlled-trials
  • nitric-oxide synthase
  • long-term treatment
  • cod-liver oil
  • eicosapentaenoic acid

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