Fish and omega-3 fatty acid intake in relation to circulating fibroblast growth factor 23 levels in renal transplant recipients

L.C. Baia, E. van den Berg, M.G. Vervloet, I.P. Heilberg, G. Navis, S.J.L. Bakker, J.M. Geleijnse, D. Kromhout, S.S. Soedamah-Muthu, M.H. de Borst

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11 Citations (Scopus)

Abstract

Background and aims A high circulating fibroblast growth factor 23 (FGF23) level is an independent risk factor for cardiovascular mortality in renal transplant recipients and the general population. N-3 fatty acids eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) may contribute to cardiovascular risk reduction. We investigated whether fish and EPA-DHA intake are related to FGF23 levels in renal transplant recipients. Methods and results We performed a cross-sectional analysis in 619 stable renal transplant recipients (mean age 53 years, 57% male, estimated glomerular filtration rate [eGFR] 53 ± 20 mL/min/1.73 m2). Dietary intake was assessed by a 177-item food frequency questionnaire. Serum intact FGF23 was measured by ELISA. We examined differences in FGF23 levels across categories of fish and EPA-DHA intake using analysis of variance models adjusted for age, sex, dietary and lifestyle factors and key determinants of FGF23. Patients consumed on average 15 g of fish and 139 mg EPA-DHA/day. Median FGF23 was 62 pg/mL (IQR 43–98 pg/mL). Higher dietary EPA-DHA and fish intake were associated with lower serum FGF23 levels. Subgroup analyses revealed that particularly in patients with reduced renal function (eGFR
Original languageEnglish
Pages (from-to)1310-1316
JournalNutrition, Metabolism & Cardiovascular Diseases
Volume24
Issue number12
DOIs
Publication statusPublished - 2014

Keywords

  • left-ventricular hypertrophy
  • klotho
  • mortality
  • disease
  • protein
  • cells
  • n-3

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