First isolation of Hepatitis E virus genotype 4 in Europe through swine surveillance in the Netherlands and Belgium.

R.W. van der Honing-Hakze; E. Van Coillie; A.F.G. Antonis; W.H.M. van der Poel

doi:10.1371/journal.pone.0022673

First isolation of Hepatitis E virus genotype 4 in Europe through swine surveillance in the Netherlands and Belgium.

R.W. van der Honing-Hakze, E. Van Coillie, A.F.G. Antonis, W.H.M. van der Poel

Virology & Molecular Biology

Research output: Contribution to journal › Article › Academic › peer-review

119 Citations (Scopus)

Abstract

Hepatitis E virus (HEV) genotypes 3 and 4 are a cause of human hepatitis and swine are considered the main reservoir. To study the HEV prevalence and characterize circulating HEV strains, fecal samples from swine in the Netherlands and Belgium were tested by RT-PCR. HEV prevalence in swine was 7–15%. The Dutch strains were characterized as genotype 3, subgroups 3a, 3c and 3f, closely related to sequences found in humans and swine earlier. The HEV strains found in Belgium belonged to genotypes 3f and 4b. The HEV genotype 4 strain was the first ever reported in swine in Europe and an experimental infection in pigs was performed to isolate the virus. The genotype 4 strain readily infected piglets and caused fever and virus shedding. Since HEV4 infections have been reported to run a more severe clinical course in humans this observation may have public health implications

Original language	English
Article number	e22673
Number of pages	6
Journal	PLoS ONE
Volume	6
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0022673
Publication status	Published - 2011

Keywords

cross-species infection
united-states
rt-pcr
prevalence
hev
epidemiology
transmission
antibodies
sequences
humans

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1371/journal.pone.0022673

Paslahepevirus balayani structural protein gene, partial cds
van der Honing-Hakze, R. W. (Creator), Van Coillie, E. (Creator), Antonis, A. F. G. (Creator) & van der Poel, W. H. M. (Creator), Wageningen University & Research, 27 Sept 2011
https://www.ncbi.nlm.nih.gov/popset/329132364
Dataset

Virusveiligheid in de dierlijke productieketen (KB-15-006-016)
van der Poel, W. (Project Leader)
26/01/11 → 31/12/14
Project: LVVN project

Cite this

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title = "First isolation of Hepatitis E virus genotype 4 in Europe through swine surveillance in the Netherlands and Belgium.",

abstract = "Hepatitis E virus (HEV) genotypes 3 and 4 are a cause of human hepatitis and swine are considered the main reservoir. To study the HEV prevalence and characterize circulating HEV strains, fecal samples from swine in the Netherlands and Belgium were tested by RT-PCR. HEV prevalence in swine was 7–15%. The Dutch strains were characterized as genotype 3, subgroups 3a, 3c and 3f, closely related to sequences found in humans and swine earlier. The HEV strains found in Belgium belonged to genotypes 3f and 4b. The HEV genotype 4 strain was the first ever reported in swine in Europe and an experimental infection in pigs was performed to isolate the virus. The genotype 4 strain readily infected piglets and caused fever and virus shedding. Since HEV4 infections have been reported to run a more severe clinical course in humans this observation may have public health implications",

keywords = "cross-species infection, united-states, rt-pcr, prevalence, hev, epidemiology, transmission, antibodies, sequences, humans",

author = "{van der Honing-Hakze}, R.W. and {Van Coillie}, E. and A.F.G. Antonis and {van der Poel}, W.H.M.",

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volume = "6",

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T1 - First isolation of Hepatitis E virus genotype 4 in Europe through swine surveillance in the Netherlands and Belgium.

AU - van der Honing-Hakze, R.W.

AU - Van Coillie, E.

AU - Antonis, A.F.G.

AU - van der Poel, W.H.M.

PY - 2011

Y1 - 2011

N2 - Hepatitis E virus (HEV) genotypes 3 and 4 are a cause of human hepatitis and swine are considered the main reservoir. To study the HEV prevalence and characterize circulating HEV strains, fecal samples from swine in the Netherlands and Belgium were tested by RT-PCR. HEV prevalence in swine was 7–15%. The Dutch strains were characterized as genotype 3, subgroups 3a, 3c and 3f, closely related to sequences found in humans and swine earlier. The HEV strains found in Belgium belonged to genotypes 3f and 4b. The HEV genotype 4 strain was the first ever reported in swine in Europe and an experimental infection in pigs was performed to isolate the virus. The genotype 4 strain readily infected piglets and caused fever and virus shedding. Since HEV4 infections have been reported to run a more severe clinical course in humans this observation may have public health implications

AB - Hepatitis E virus (HEV) genotypes 3 and 4 are a cause of human hepatitis and swine are considered the main reservoir. To study the HEV prevalence and characterize circulating HEV strains, fecal samples from swine in the Netherlands and Belgium were tested by RT-PCR. HEV prevalence in swine was 7–15%. The Dutch strains were characterized as genotype 3, subgroups 3a, 3c and 3f, closely related to sequences found in humans and swine earlier. The HEV strains found in Belgium belonged to genotypes 3f and 4b. The HEV genotype 4 strain was the first ever reported in swine in Europe and an experimental infection in pigs was performed to isolate the virus. The genotype 4 strain readily infected piglets and caused fever and virus shedding. Since HEV4 infections have been reported to run a more severe clinical course in humans this observation may have public health implications

KW - cross-species infection

KW - united-states

KW - rt-pcr

KW - prevalence

KW - hev

KW - epidemiology

KW - transmission

KW - antibodies

KW - sequences

KW - humans

U2 - 10.1371/journal.pone.0022673

DO - 10.1371/journal.pone.0022673

M3 - Article

SN - 1932-6203

VL - 6

JO - PLoS ONE

JF - PLoS ONE

IS - 8

M1 - e22673

ER -

First isolation of Hepatitis E virus genotype 4 in Europe through swine surveillance in the Netherlands and Belgium.

Abstract

Keywords

UN SDGs

Access to Document

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Datasets

Paslahepevirus balayani structural protein gene, partial cds

Projects

Virusveiligheid in de dierlijke productieketen (KB-15-006-016)

Cite this