Fine Scale Spatiotemporal Clustering of Dengue Virus Transmission in Children and Aedes aegypti in Rural Thai Villages

I.K. Yoon, A. Getis, J. Aldstadt, A.L. Rothman, D. Tannitisupawong, C.J.M. Koenraadt, T. Fansiri, J.W. Jones, A.C. Morrison, R.G. Jarman, A. Nisalak, M.P. Mammen Jr., S. Thammapalo, A. Srikiatkhachorn, S. Green, D.H. Libraty, R.V. Gibbons, T. Endy, C. Pimgate, T.W. Scott

Research output: Contribution to journalArticleAcademicpeer-review

116 Citations (Scopus)

Abstract

Background Based on spatiotemporal clustering of human dengue virus (DENV) infections, transmission is thought to occur at fine spatiotemporal scales by horizontal transfer of virus between humans and mosquito vectors. To define the dimensions of local transmission and quantify the factors that support it, we examined relationships between infected humans and Aedes aegypti in Thai villages. Methodology/Principal Findings Geographic cluster investigations of 100-meter radius were conducted around DENV-positive and DENV-negative febrile “index” cases (positive and negative clusters, respectively) from a longitudinal cohort study in rural Thailand. Child contacts and Ae. aegypti from cluster houses were assessed for DENV infection. Spatiotemporal, demographic, and entomological parameters were evaluated. In positive clusters, the DENV infection rate among child contacts was 35.3% in index houses, 29.9% in houses within 20 meters, and decreased with distance from the index house to 6.2% in houses 80–100 meters away (p
Original languageEnglish
Article numbere1730
JournalPLoS Neglected Tropical Diseases
Volume6
Issue number7
DOIs
Publication statusPublished - 2012

Keywords

  • polymerase-chain-reaction
  • primary-school children
  • kamphaeng phet
  • puerto-rico
  • vector
  • culicidae
  • diptera
  • blood
  • patterns
  • kinetics

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