Fetal protection against BVDV fetal infection six months after vaccination with a novel inactivated BVDV vaccine

S. Harmeyer, A.F.G. Antonis, T. Gadd, J. Salt, S. Jahnecke, A. Brune

    Research output: Contribution to journalArticleAcademicpeer-review

    2 Citations (Scopus)

    Abstract

    Two studies including a total of 59 heifers were conducted to determine the extent and duration of either the protection against a fetal BVDV infection or the presence of BVDV neutralising antibodies after vaccination with PregSure((R)) BVD, an inactivated BVDV type I vaccine. Following the primary vaccination schedule consisting of two injections at a 3 week interval the fetal protection rate was 100% using a challenge model that caused fetal infection in 100% in the control heifers. The duration of the protection was demonstrated at 6 months. Furthermore, vaccination also clearly reduced signs associated with BVDV infections, such as BVDV viraemia and nasal excretion. A single booster injection given 12 months after the primary vaccination course stimulated a strong memory response in BVDV neutralising antibodies even exceeding the response seen after the initial vaccination regime.
    Original languageEnglish
    Pages (from-to)663-+
    JournalTierärztliche Umschau: Zeitschrift fuer alle Gebiete der Veterinaermedizin
    Volume59
    Issue number11
    Publication statusPublished - 2004

    Keywords

    • viral diarrhea virus

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