Fetal protection against BVDV fetal infection six months after vaccination with a novel inactivated BVDV vaccine

S. Harmeyer; A.F.G. Antonis; T. Gadd; J. Salt; S. Jahnecke; A. Brune

Fetal protection against BVDV fetal infection six months after vaccination with a novel inactivated BVDV vaccine

S. Harmeyer, A.F.G. Antonis, T. Gadd, J. Salt, S. Jahnecke, A. Brune

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Two studies including a total of 59 heifers were conducted to determine the extent and duration of either the protection against a fetal BVDV infection or the presence of BVDV neutralising antibodies after vaccination with PregSure((R)) BVD, an inactivated BVDV type I vaccine. Following the primary vaccination schedule consisting of two injections at a 3 week interval the fetal protection rate was 100% using a challenge model that caused fetal infection in 100% in the control heifers. The duration of the protection was demonstrated at 6 months. Furthermore, vaccination also clearly reduced signs associated with BVDV infections, such as BVDV viraemia and nasal excretion. A single booster injection given 12 months after the primary vaccination course stimulated a strong memory response in BVDV neutralising antibodies even exceeding the response seen after the initial vaccination regime.

Original language	English
Pages (from-to)	663-+
Journal	Tierärztliche Umschau: Zeitschrift fuer alle Gebiete der Veterinaermedizin
Volume	59
Issue number	11
Publication status	Published - 2004

Keywords

viral diarrhea virus

Cite this

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title = "Fetal protection against BVDV fetal infection six months after vaccination with a novel inactivated BVDV vaccine",

abstract = "Two studies including a total of 59 heifers were conducted to determine the extent and duration of either the protection against a fetal BVDV infection or the presence of BVDV neutralising antibodies after vaccination with PregSure((R)) BVD, an inactivated BVDV type I vaccine. Following the primary vaccination schedule consisting of two injections at a 3 week interval the fetal protection rate was 100% using a challenge model that caused fetal infection in 100% in the control heifers. The duration of the protection was demonstrated at 6 months. Furthermore, vaccination also clearly reduced signs associated with BVDV infections, such as BVDV viraemia and nasal excretion. A single booster injection given 12 months after the primary vaccination course stimulated a strong memory response in BVDV neutralising antibodies even exceeding the response seen after the initial vaccination regime.",

keywords = "viral diarrhea virus",

author = "S. Harmeyer and A.F.G. Antonis and T. Gadd and J. Salt and S. Jahnecke and A. Brune",

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year = "2004",

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pages = "663--+",

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Fetal protection against BVDV fetal infection six months after vaccination with a novel inactivated BVDV vaccine. / Harmeyer, S.; Antonis, A.F.G.; Gadd, T.; Salt, J.; Jahnecke, S.; Brune, A.

In: Tierärztliche Umschau: Zeitschrift fuer alle Gebiete der Veterinaermedizin, Vol. 59, No. 11, 2004, p. 663-+.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Fetal protection against BVDV fetal infection six months after vaccination with a novel inactivated BVDV vaccine

AU - Harmeyer, S.

AU - Antonis, A.F.G.

AU - Gadd, T.

AU - Salt, J.

AU - Jahnecke, S.

AU - Brune, A.

N1 - ISI:000224901600006

PY - 2004

Y1 - 2004

N2 - Two studies including a total of 59 heifers were conducted to determine the extent and duration of either the protection against a fetal BVDV infection or the presence of BVDV neutralising antibodies after vaccination with PregSure((R)) BVD, an inactivated BVDV type I vaccine. Following the primary vaccination schedule consisting of two injections at a 3 week interval the fetal protection rate was 100% using a challenge model that caused fetal infection in 100% in the control heifers. The duration of the protection was demonstrated at 6 months. Furthermore, vaccination also clearly reduced signs associated with BVDV infections, such as BVDV viraemia and nasal excretion. A single booster injection given 12 months after the primary vaccination course stimulated a strong memory response in BVDV neutralising antibodies even exceeding the response seen after the initial vaccination regime.

AB - Two studies including a total of 59 heifers were conducted to determine the extent and duration of either the protection against a fetal BVDV infection or the presence of BVDV neutralising antibodies after vaccination with PregSure((R)) BVD, an inactivated BVDV type I vaccine. Following the primary vaccination schedule consisting of two injections at a 3 week interval the fetal protection rate was 100% using a challenge model that caused fetal infection in 100% in the control heifers. The duration of the protection was demonstrated at 6 months. Furthermore, vaccination also clearly reduced signs associated with BVDV infections, such as BVDV viraemia and nasal excretion. A single booster injection given 12 months after the primary vaccination course stimulated a strong memory response in BVDV neutralising antibodies even exceeding the response seen after the initial vaccination regime.

KW - viral diarrhea virus

M3 - Article

VL - 59

SP - 663-+

JO - Tierärztliche Umschau: Zeitschrift fuer alle Gebiete der Veterinaermedizin

JF - Tierärztliche Umschau: Zeitschrift fuer alle Gebiete der Veterinaermedizin

SN - 0049-3864

IS - 11

ER -

Fetal protection against BVDV fetal infection six months after vaccination with a novel inactivated BVDV vaccine

Abstract

Keywords

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