FEMA GRAS assessment of natural flavor complexes

Cinnamomum and Myroxylon-derived flavoring ingredients

Ivonne M.C.M. Rietjens, Samuel M. Cohen, Gerhard Eisenbrand, Shoji Fukushima, Nigel J. Gooderham, Peter F. Guengerich, Stephen S. Hecht, Thomas J. Rosol, Jeanne M. Davidsen, Christie L. Harman, Ian J. Murray, Sean V. Taylor*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

In 2015, the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA) initiated a program for the re-evaluation of the safety of over 250 natural flavor complexes (NFCs) used as flavor ingredients. This publication, third in the series, considers NFCs composed primarily of constituents with the 3-phenyl-2-propenyl or a cinnamyl functional group, using the procedure outlined in 2005 and updated in 2018 to evaluate the safety of naturally-occurring mixtures for their intended use as flavor ingredients. The procedure relies on a complete chemical characterization of the NFC intended for commerce and organization of each NFC's chemical constituents into well-defined congeneric groups. The safety of the NFC is evaluated using the well-established and conservative threshold of toxicological concern (TTC) concept in addition to data on absorption, metabolism and toxicology of members of the congeneric groups and the NFC under evaluation. Six NFCs from the Myroxylon and Cinnamomum genera, Balsam Oil, Peru (FEMA 2117), Tolu Balsam Extract (FEMA 3069), Cassia Bark Extract (FEMA 2257), Cassia Bark Oil (FEMA 2258), Cinnamon Bark Extract (FEMA 2290) and Cinnamon Bark Oil (FEMA 2291) were evaluated and affirmed as generally recognized as safe (GRAS) under their conditions of intended use as flavor ingredients.

Original languageEnglish
Article number110949
JournalFood and Chemical Toxicology
Volume135
DOIs
Publication statusPublished - Jan 2020

Fingerprint

Myroxylon
Cinnamomum
Flavors
flavorings
Cassia
ingredients
flavor
Safety
extracts
Oils
Cinnamomum zeylanicum
Program Evaluation
Toxicology
Cinnamomum aromaticum
cinnamon
oils
Myroxylon balsamum
bark

Keywords

  • Balsam essential oil and extract
  • Cinnamon and cassia essential oils and extracts
  • GRAS
  • Natural flavor complex
  • Safety evaluation

Cite this

Rietjens, Ivonne M.C.M. ; Cohen, Samuel M. ; Eisenbrand, Gerhard ; Fukushima, Shoji ; Gooderham, Nigel J. ; Guengerich, Peter F. ; Hecht, Stephen S. ; Rosol, Thomas J. ; Davidsen, Jeanne M. ; Harman, Christie L. ; Murray, Ian J. ; Taylor, Sean V. / FEMA GRAS assessment of natural flavor complexes : Cinnamomum and Myroxylon-derived flavoring ingredients. In: Food and Chemical Toxicology. 2020 ; Vol. 135.
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abstract = "In 2015, the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA) initiated a program for the re-evaluation of the safety of over 250 natural flavor complexes (NFCs) used as flavor ingredients. This publication, third in the series, considers NFCs composed primarily of constituents with the 3-phenyl-2-propenyl or a cinnamyl functional group, using the procedure outlined in 2005 and updated in 2018 to evaluate the safety of naturally-occurring mixtures for their intended use as flavor ingredients. The procedure relies on a complete chemical characterization of the NFC intended for commerce and organization of each NFC's chemical constituents into well-defined congeneric groups. The safety of the NFC is evaluated using the well-established and conservative threshold of toxicological concern (TTC) concept in addition to data on absorption, metabolism and toxicology of members of the congeneric groups and the NFC under evaluation. Six NFCs from the Myroxylon and Cinnamomum genera, Balsam Oil, Peru (FEMA 2117), Tolu Balsam Extract (FEMA 3069), Cassia Bark Extract (FEMA 2257), Cassia Bark Oil (FEMA 2258), Cinnamon Bark Extract (FEMA 2290) and Cinnamon Bark Oil (FEMA 2291) were evaluated and affirmed as generally recognized as safe (GRAS) under their conditions of intended use as flavor ingredients.",
keywords = "Balsam essential oil and extract, Cinnamon and cassia essential oils and extracts, GRAS, Natural flavor complex, Safety evaluation",
author = "Rietjens, {Ivonne M.C.M.} and Cohen, {Samuel M.} and Gerhard Eisenbrand and Shoji Fukushima and Gooderham, {Nigel J.} and Guengerich, {Peter F.} and Hecht, {Stephen S.} and Rosol, {Thomas J.} and Davidsen, {Jeanne M.} and Harman, {Christie L.} and Murray, {Ian J.} and Taylor, {Sean V.}",
year = "2020",
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doi = "10.1016/j.fct.2019.110949",
language = "English",
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Rietjens, IMCM, Cohen, SM, Eisenbrand, G, Fukushima, S, Gooderham, NJ, Guengerich, PF, Hecht, SS, Rosol, TJ, Davidsen, JM, Harman, CL, Murray, IJ & Taylor, SV 2020, 'FEMA GRAS assessment of natural flavor complexes: Cinnamomum and Myroxylon-derived flavoring ingredients', Food and Chemical Toxicology, vol. 135, 110949. https://doi.org/10.1016/j.fct.2019.110949

FEMA GRAS assessment of natural flavor complexes : Cinnamomum and Myroxylon-derived flavoring ingredients. / Rietjens, Ivonne M.C.M.; Cohen, Samuel M.; Eisenbrand, Gerhard; Fukushima, Shoji; Gooderham, Nigel J.; Guengerich, Peter F.; Hecht, Stephen S.; Rosol, Thomas J.; Davidsen, Jeanne M.; Harman, Christie L.; Murray, Ian J.; Taylor, Sean V.

In: Food and Chemical Toxicology, Vol. 135, 110949, 01.2020.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - FEMA GRAS assessment of natural flavor complexes

T2 - Cinnamomum and Myroxylon-derived flavoring ingredients

AU - Rietjens, Ivonne M.C.M.

AU - Cohen, Samuel M.

AU - Eisenbrand, Gerhard

AU - Fukushima, Shoji

AU - Gooderham, Nigel J.

AU - Guengerich, Peter F.

AU - Hecht, Stephen S.

AU - Rosol, Thomas J.

AU - Davidsen, Jeanne M.

AU - Harman, Christie L.

AU - Murray, Ian J.

AU - Taylor, Sean V.

PY - 2020/1

Y1 - 2020/1

N2 - In 2015, the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA) initiated a program for the re-evaluation of the safety of over 250 natural flavor complexes (NFCs) used as flavor ingredients. This publication, third in the series, considers NFCs composed primarily of constituents with the 3-phenyl-2-propenyl or a cinnamyl functional group, using the procedure outlined in 2005 and updated in 2018 to evaluate the safety of naturally-occurring mixtures for their intended use as flavor ingredients. The procedure relies on a complete chemical characterization of the NFC intended for commerce and organization of each NFC's chemical constituents into well-defined congeneric groups. The safety of the NFC is evaluated using the well-established and conservative threshold of toxicological concern (TTC) concept in addition to data on absorption, metabolism and toxicology of members of the congeneric groups and the NFC under evaluation. Six NFCs from the Myroxylon and Cinnamomum genera, Balsam Oil, Peru (FEMA 2117), Tolu Balsam Extract (FEMA 3069), Cassia Bark Extract (FEMA 2257), Cassia Bark Oil (FEMA 2258), Cinnamon Bark Extract (FEMA 2290) and Cinnamon Bark Oil (FEMA 2291) were evaluated and affirmed as generally recognized as safe (GRAS) under their conditions of intended use as flavor ingredients.

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KW - Balsam essential oil and extract

KW - Cinnamon and cassia essential oils and extracts

KW - GRAS

KW - Natural flavor complex

KW - Safety evaluation

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DO - 10.1016/j.fct.2019.110949

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