Feather segmentation to discriminate between different enrofloxacin treatments in order to monitor off-label use in the poultry sector

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)

Abstract

Antibiotics are commonly used in the poultry industry
to treat bacterial infections. In the combat against bacterial
resistance, policies require, besides a reduction of antibiotic
usage in humans and animals, an up-to-date farmer
registration mentioning all treatments. For enforcement of
such policies, tests are needed to antedate administration and
to determine the type of treatment so as to prevent off-label
use and the supervacaneous use of last-resort antibiotics like
cephalosporins and fluoroquinolones. After poultry treatment,
high amounts of enrofloxacin and its metabolite ciprofloxacin
are deposited in chicken feathers. A method is presented to
discriminate different treatments based on differentiating extractable
and non-extractable enrofloxacin and ciprofloxacin
in chicken feathers.With this approach, we show it is possible
to distinguish between a registered therapeutic oral treatment,
an off-label spray treatment and an illegal prolonged subtherapeutic
treatment with enrofloxacin. This approach is a
new and strong tool in the enforcement of new policies in
the fight against off-label and supervacaneous antibiotic use.
Original languageEnglish
Pages (from-to)495-502
JournalAnalytical and Bioanalytical Chemistry
Volume408
DOIs
Publication statusPublished - 2016

Fingerprint Dive into the research topics of 'Feather segmentation to discriminate between different enrofloxacin treatments in order to monitor off-label use in the poultry sector'. Together they form a unique fingerprint.

Cite this