Fat, fibre and cancer risk in African Americans and rural Africans

S.J. O'Keefe, J.V. Li, L.M. Lahti, J. Ou, F. Carbonero, K. Mohammed, J.M. Posma, J. Kinross, E. Wahl, E. Ruder, K. Vipperla, V. Naidoo, L. Mtshali, S. Tims, P.G.B. Puylaert, J. DeLany, A. Krasinskas, A.C. Benefiel, H.O. Kaseb, K. NewtonJ.K. Nicholson, W.M. de Vos, H.R. Gaskins, E.G. Zoetendal

Research output: Contribution to journalArticleAcademicpeer-review

360 Citations (Scopus)


Rates of colon cancer are much higher in African Americans (65:100,000) than in rural South Africans (
Original languageEnglish
Article number6342
JournalNature Communications
Publication statusPublished - 2015


  • butyrate-producing bacteria
  • resistant starch
  • colon-cancer
  • cell-proliferation
  • phylogenetic microarray
  • microbial metabolites
  • intestinal-mucosa
  • epithelial-cells
  • gene-expression
  • human feces

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  • Projects

    MICROBESINSIDE: Exploitation of Our Intestinal Microbiota


    Project: EU research project

    Cite this

    O'Keefe, S. J., Li, J. V., Lahti, L. M., Ou, J., Carbonero, F., Mohammed, K., Posma, J. M., Kinross, J., Wahl, E., Ruder, E., Vipperla, K., Naidoo, V., Mtshali, L., Tims, S., Puylaert, P. G. B., DeLany, J., Krasinskas, A., Benefiel, A. C., Kaseb, H. O., ... Zoetendal, E. G. (2015). Fat, fibre and cancer risk in African Americans and rural Africans. Nature Communications, 6, [6342]. https://doi.org/10.1038/ncomms7342