Familial follicular cell thyroid carcinomas in a large number of Dutch German longhaired pointers

Yun Yu*, Adriana Krupa, Rebekah I. Keesler, Guy C.M. Grinwis, Mariska de Ruijsscher, Johan de Vos, Martien A.M. Groenen, Richard P.M.A. Crooijmans*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Abstract

Thyroid carcinomas (TCs) originating from follicular cells of the thyroid gland occur in both humans and dogs, and they have highly similar histomorphologic patterns. In dogs, TCs have not been extensively investigated, especially concerning the familial origin of TCs. Here, we report familial thyroid follicular cell carcinomas (FCCs) confirmed by histology in 54 Dutch origin German longhaired pointers. From the pedigree, 45 of 54 histopathologically confirmed cases are closely related to a pair of first-half cousins in the past, indicating a familial disease. In addition, genetics contributed more to the thyroid FCC than other factors by an estimated heritability of 0.62 based on pedigree. The age of diagnosis ranged between 4.5 and 13.5 years, and 76% of cases were diagnosed before 10 years of age, implying an early onset of disease. We observed a significant higher pedigree-based inbreeding coefficient in the affected dogs (mean F, 0.23) compared to unaffected dogs (mean F, 0.14), suggesting the contribution of inbreeding to tumour development. The unique occurrence of familial thyroid FCC in this dog population and the large number of affected dogs make this population an important model to identify the genetic basis of familial thyroid FCC in this breed and may contribute to the research into pathogenesis, prevention and treatment in humans.

Original languageEnglish
Pages (from-to)227-234
JournalVeterinary and Comparative Oncology
Volume20
Issue number1
Early online date31 Aug 2021
DOIs
Publication statusPublished - Mar 2022

Keywords

  • dog
  • heritable cancer
  • inbreeding
  • thyroid carcinoma

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