Faecalibacterium prausnitzii and human intestinal health

S. Miquel; R. Martin; O. Rossi; L.G. Bermudez-Humaran; J.M. Chatel; H. Sokol; M. Thomas; J.M. Wells; P. Langella

doi:10.1016/j.mib.2013.06.003

Faecalibacterium prausnitzii and human intestinal health

S. Miquel, R. Martin, O. Rossi, L.G. Bermudez-Humaran, J.M. Chatel, H. Sokol, M. Thomas, J.M. Wells, P. Langella

Research output: Contribution to journal › Article › Academic › peer-review

419 Citations (Scopus)

Abstract

Faecalibacterium prausnitzii is the most abundant bacterium in the human intestinal microbiota of healthy adults, representing more than 5% of the total bacterial population. Over the past five years, an increasing number of studies have clearly described the importance of this highly metabolically active commensal bacterium as a component of the healthy human microbiota. Changes in the abundance of F. prausnitzii have been linked to dysbiosis in several human disorders. Administration of F. prausnitzii strain A2-165 and its culture supernatant have been shown to protect against 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in mice. Here, we discuss the role of F. prausnitzii in balancing immunity in the intestine and the mechanisms involved.

Original language	English
Pages (from-to)	255-261
Journal	Current Opinion in Microbiology
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/j.mib.2013.06.003
Publication status	Published - 2013

Keywords

16s ribosomal-rna
irritable-bowel-syndrome
mucosa-associated microbiota
butyrate-producing bacteria
active crohns-disease
gut microbiota
ulcerative-colitis
fecal microbiota
fusobacterium-prausnitzii
gastrointestinal-tract

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title = "Faecalibacterium prausnitzii and human intestinal health",

abstract = "Faecalibacterium prausnitzii is the most abundant bacterium in the human intestinal microbiota of healthy adults, representing more than 5% of the total bacterial population. Over the past five years, an increasing number of studies have clearly described the importance of this highly metabolically active commensal bacterium as a component of the healthy human microbiota. Changes in the abundance of F. prausnitzii have been linked to dysbiosis in several human disorders. Administration of F. prausnitzii strain A2-165 and its culture supernatant have been shown to protect against 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in mice. Here, we discuss the role of F. prausnitzii in balancing immunity in the intestine and the mechanisms involved.",

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T1 - Faecalibacterium prausnitzii and human intestinal health

AU - Miquel, S.

AU - Martin, R.

AU - Rossi, O.

AU - Bermudez-Humaran, L.G.

AU - Chatel, J.M.

AU - Sokol, H.

AU - Thomas, M.

AU - Wells, J.M.

AU - Langella, P.

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PY - 2013

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N2 - Faecalibacterium prausnitzii is the most abundant bacterium in the human intestinal microbiota of healthy adults, representing more than 5% of the total bacterial population. Over the past five years, an increasing number of studies have clearly described the importance of this highly metabolically active commensal bacterium as a component of the healthy human microbiota. Changes in the abundance of F. prausnitzii have been linked to dysbiosis in several human disorders. Administration of F. prausnitzii strain A2-165 and its culture supernatant have been shown to protect against 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in mice. Here, we discuss the role of F. prausnitzii in balancing immunity in the intestine and the mechanisms involved.

AB - Faecalibacterium prausnitzii is the most abundant bacterium in the human intestinal microbiota of healthy adults, representing more than 5% of the total bacterial population. Over the past five years, an increasing number of studies have clearly described the importance of this highly metabolically active commensal bacterium as a component of the healthy human microbiota. Changes in the abundance of F. prausnitzii have been linked to dysbiosis in several human disorders. Administration of F. prausnitzii strain A2-165 and its culture supernatant have been shown to protect against 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in mice. Here, we discuss the role of F. prausnitzii in balancing immunity in the intestine and the mechanisms involved.

KW - 16s ribosomal-rna

KW - irritable-bowel-syndrome

KW - mucosa-associated microbiota

KW - butyrate-producing bacteria

KW - active crohns-disease

KW - gut microbiota

KW - ulcerative-colitis

KW - fecal microbiota

KW - fusobacterium-prausnitzii

KW - gastrointestinal-tract

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DO - 10.1016/j.mib.2013.06.003

M3 - Article

VL - 16

SP - 255

EP - 261

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

SN - 1369-5274

IS - 3

ER -