Abstract
Faecalibacterium prausnitzii is the most abundant bacterium in the human intestinal microbiota of healthy adults, representing more than 5% of the total bacterial population. Over the past five years, an increasing number of studies have clearly described the importance of this highly metabolically active commensal bacterium as a component of the healthy human microbiota. Changes in the abundance of F. prausnitzii have been linked to dysbiosis in several human disorders. Administration of F. prausnitzii strain A2-165 and its culture supernatant have been shown to protect against 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in mice. Here, we discuss the role of F. prausnitzii in balancing immunity in the intestine and the mechanisms involved.
Original language | English |
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Pages (from-to) | 255-261 |
Journal | Current Opinion in Microbiology |
Volume | 16 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2013 |
Keywords
- 16s ribosomal-rna
- irritable-bowel-syndrome
- mucosa-associated microbiota
- butyrate-producing bacteria
- active crohns-disease
- gut microbiota
- ulcerative-colitis
- fecal microbiota
- fusobacterium-prausnitzii
- gastrointestinal-tract