Faecalibacterium prausnitzii and human intestinal health

S. Miquel, R. Martin, O. Rossi, L.G. Bermudez-Humaran, J.M. Chatel, H. Sokol, M. Thomas, J.M. Wells, P. Langella

Research output: Contribution to journalArticleAcademicpeer-review

419 Citations (Scopus)

Abstract

Faecalibacterium prausnitzii is the most abundant bacterium in the human intestinal microbiota of healthy adults, representing more than 5% of the total bacterial population. Over the past five years, an increasing number of studies have clearly described the importance of this highly metabolically active commensal bacterium as a component of the healthy human microbiota. Changes in the abundance of F. prausnitzii have been linked to dysbiosis in several human disorders. Administration of F. prausnitzii strain A2-165 and its culture supernatant have been shown to protect against 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in mice. Here, we discuss the role of F. prausnitzii in balancing immunity in the intestine and the mechanisms involved.
Original languageEnglish
Pages (from-to)255-261
JournalCurrent Opinion in Microbiology
Volume16
Issue number3
DOIs
Publication statusPublished - 2013

Keywords

  • 16s ribosomal-rna
  • irritable-bowel-syndrome
  • mucosa-associated microbiota
  • butyrate-producing bacteria
  • active crohns-disease
  • gut microbiota
  • ulcerative-colitis
  • fecal microbiota
  • fusobacterium-prausnitzii
  • gastrointestinal-tract

Fingerprint Dive into the research topics of 'Faecalibacterium prausnitzii and human intestinal health'. Together they form a unique fingerprint.

Cite this