Faecalibacterium prausnitzii and human intestinal health

S. Miquel, R. Martin, O. Rossi, L.G. Bermudez-Humaran, J.M. Chatel, H. Sokol, M. Thomas, J.M. Wells, P. Langella

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Abstract

Faecalibacterium prausnitzii is the most abundant bacterium in the human intestinal microbiota of healthy adults, representing more than 5% of the total bacterial population. Over the past five years, an increasing number of studies have clearly described the importance of this highly metabolically active commensal bacterium as a component of the healthy human microbiota. Changes in the abundance of F. prausnitzii have been linked to dysbiosis in several human disorders. Administration of F. prausnitzii strain A2-165 and its culture supernatant have been shown to protect against 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in mice. Here, we discuss the role of F. prausnitzii in balancing immunity in the intestine and the mechanisms involved.
Original languageEnglish
Pages (from-to)255-261
JournalCurrent Opinion in Microbiology
Volume16
Issue number3
DOIs
Publication statusPublished - 2013

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Keywords

  • 16s ribosomal-rna
  • irritable-bowel-syndrome
  • mucosa-associated microbiota
  • butyrate-producing bacteria
  • active crohns-disease
  • gut microbiota
  • ulcerative-colitis
  • fecal microbiota
  • fusobacterium-prausnitzii
  • gastrointestinal-tract

Cite this

Miquel, S., Martin, R., Rossi, O., Bermudez-Humaran, L. G., Chatel, J. M., Sokol, H., ... Langella, P. (2013). Faecalibacterium prausnitzii and human intestinal health. Current Opinion in Microbiology, 16(3), 255-261. https://doi.org/10.1016/j.mib.2013.06.003