Facile enzymatic Cγ-acylation of lignin model compounds

Roelant Hilgers, Jean Paul Vincken, Mirjam A. Kabel*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)


Simple β-O-4’ linked dimeric model compounds are often targeted as substrate to mimic the reactivity of lignin in enzymatic or chemical treatments. These models mimic the structure and reactivity of regular β-O-4′ linkages in lignin, but are less suitable to predict the reactivity of acylated β-O-4′ substructures, which are abundant in various types of lignin. Here, we present a one-step lipase-catalyzed acylation of a commercially available lignin model compound with p-coumaric acid, p-hydroxybenzoic acid, cinnamic acid and acetic acid as acyl donors. This facile procedure allows to obtain new and relevant lignin model compounds at milligram scale, with simple purification of products and unreacted substrate.

Original languageEnglish
Article number105919
JournalCatalysis Communications
Publication statusPublished - 1 Mar 2020


  • CALB
  • Esterification
  • Lipase
  • p-coumaric acid
  • p-hydroxybenzoic acid
  • Synthesis

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