Greenhouses are expanding fast in arid and semi-arid regions, among other reasons, because of the water savings that can be realized compared to open field cultivation. However, it is difficult for growers to recognize the optimum greenhouse design. Many competing aspects must be weighed against each other such as the structure, the cover and the climate control equipment. Obviously, the optimum design must be tailored for each specific crop and growing cycle and availability of resources (land, water, energy, labor, etc.). Simulation models can assist in this process, saving time and money. Wageningen University & Research, BU Greenhouse Horticulture has developed the Adaptive Greenhouse Methodology. It combines the use of greenhouse climate and resources simulation models, with crop growth and economic models, to solve the problem of designing the optimum greenhouse for each specific scenario in the world. In the present work we present the results of the application of this methodology to the specific case of the production of greenhouse soilless tomato in two regions in Jordan in the mid tech range: the highlands and the Jordan Valley. Results show that different mid tech designs could potentially provide yield levels of up to 35 and 27 kg m-2 in the Highlands and the Jordan Valley, respectively. The final design is similar in the two locations.