Exploration of blood lipoprotein and lipid fraction profiles in healthy subjects through integrated univariate, multivariate, and network analysis reveals association of lipase activity and cholesterol esterification with sex and age

Yasmijn Balder; Alessia Vignoli; Leonardo Tenori; Claudio Luchinat; Edoardo Saccenti

doi:10.3390/metabo11050326

Exploration of blood lipoprotein and lipid fraction profiles in healthy subjects through integrated univariate, multivariate, and network analysis reveals association of lipase activity and cholesterol esterification with sex and age

Yasmijn Balder, Alessia Vignoli, Leonardo Tenori, Claudio Luchinat, Edoardo Saccenti^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Scopus)

Abstract

In this study, we investigated blood lipoprotein and lipid fraction profiles, quantified using nuclear magnetic resonance, in a cohort of 844 healthy blood donors, integrating standard univariate and multivariate analysis with predictive modeling and network analysis. We observed a strong association of lipoprotein and lipid main fraction profiles with sex and age. Our results suggest an age-dependent remodulation of lipase lipoprotein activity in men and a change in the mechanisms controlling the ratio between esterified and non-esterified cholesterol in both men and women.

Original language	English
Article number	326
Journal	Metabolites
Volume	11
Issue number	5
DOIs	https://doi.org/10.3390/metabo11050326
Publication status	Published - 18 May 2021

Keywords

Analysis of biological networks
Lipid metabolism
Lipidomics
Metabolomics
Nuclear magnetic resonance

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/metabo11050326Licence: CC BY

https://edepot.wur.nl/549661Licence: CC BY

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Balder, Y., Vignoli, A., Tenori, L., Luchinat, C., & Saccenti, E. (2021). Exploration of blood lipoprotein and lipid fraction profiles in healthy subjects through integrated univariate, multivariate, and network analysis reveals association of lipase activity and cholesterol esterification with sex and age. Metabolites, 11(5), [326]. https://doi.org/10.3390/metabo11050326

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title = "Exploration of blood lipoprotein and lipid fraction profiles in healthy subjects through integrated univariate, multivariate, and network analysis reveals association of lipase activity and cholesterol esterification with sex and age",

abstract = "In this study, we investigated blood lipoprotein and lipid fraction profiles, quantified using nuclear magnetic resonance, in a cohort of 844 healthy blood donors, integrating standard univariate and multivariate analysis with predictive modeling and network analysis. We observed a strong association of lipoprotein and lipid main fraction profiles with sex and age. Our results suggest an age-dependent remodulation of lipase lipoprotein activity in men and a change in the mechanisms controlling the ratio between esterified and non-esterified cholesterol in both men and women.",

keywords = "Analysis of biological networks, Lipid metabolism, Lipidomics, Metabolomics, Nuclear magnetic resonance",

author = "Yasmijn Balder and Alessia Vignoli and Leonardo Tenori and Claudio Luchinat and Edoardo Saccenti",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = may,

day = "18",

doi = "10.3390/metabo11050326",

language = "English",

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Balder, Y, Vignoli, A, Tenori, L, Luchinat, C & Saccenti, E 2021, 'Exploration of blood lipoprotein and lipid fraction profiles in healthy subjects through integrated univariate, multivariate, and network analysis reveals association of lipase activity and cholesterol esterification with sex and age', Metabolites, vol. 11, no. 5, 326. https://doi.org/10.3390/metabo11050326

Exploration of blood lipoprotein and lipid fraction profiles in healthy subjects through integrated univariate, multivariate, and network analysis reveals association of lipase activity and cholesterol esterification with sex and age. / Balder, Yasmijn; Vignoli, Alessia; Tenori, Leonardo et al.
In: Metabolites, Vol. 11, No. 5, 326, 18.05.2021.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Exploration of blood lipoprotein and lipid fraction profiles in healthy subjects through integrated univariate, multivariate, and network analysis reveals association of lipase activity and cholesterol esterification with sex and age

AU - Balder, Yasmijn

AU - Vignoli, Alessia

AU - Tenori, Leonardo

AU - Luchinat, Claudio

AU - Saccenti, Edoardo

PY - 2021/5/18

Y1 - 2021/5/18

N2 - In this study, we investigated blood lipoprotein and lipid fraction profiles, quantified using nuclear magnetic resonance, in a cohort of 844 healthy blood donors, integrating standard univariate and multivariate analysis with predictive modeling and network analysis. We observed a strong association of lipoprotein and lipid main fraction profiles with sex and age. Our results suggest an age-dependent remodulation of lipase lipoprotein activity in men and a change in the mechanisms controlling the ratio between esterified and non-esterified cholesterol in both men and women.

AB - In this study, we investigated blood lipoprotein and lipid fraction profiles, quantified using nuclear magnetic resonance, in a cohort of 844 healthy blood donors, integrating standard univariate and multivariate analysis with predictive modeling and network analysis. We observed a strong association of lipoprotein and lipid main fraction profiles with sex and age. Our results suggest an age-dependent remodulation of lipase lipoprotein activity in men and a change in the mechanisms controlling the ratio between esterified and non-esterified cholesterol in both men and women.

KW - Analysis of biological networks

KW - Lipid metabolism

KW - Lipidomics

KW - Metabolomics

KW - Nuclear magnetic resonance

UR - https://doi.org/10.21228/M8470J

U2 - 10.3390/metabo11050326

DO - 10.3390/metabo11050326

M3 - Article

AN - SCOPUS:85107305764

SN - 2218-1989

VL - 11

JO - Metabolites

JF - Metabolites

IS - 5

M1 - 326

ER -

Exploration of blood lipoprotein and lipid fraction profiles in healthy subjects through integrated univariate, multivariate, and network analysis reveals association of lipase activity and cholesterol esterification with sex and age

Abstract

Keywords

UN SDGs

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