TY - JOUR
T1 - Experimental infrastructure requirements for quantitative research on microbial communities
AU - Kleerebezem, Robbert
AU - Stouten, Gerben
AU - Koehorst, Jasper
AU - Langenhoff, Alette
AU - Schaap, Peter
AU - Smidt, Hauke
PY - 2021/2/14
Y1 - 2021/2/14
N2 - Natural microbial communities are composed of a large diversity of interacting microorganisms, each with a specific role in the functional properties of the ecosystem. The objectives in microbial ecology research are related to identifying, understanding and exploring the role of these different microorganisms. Because of the rapidly increasing power of DNA sequencing and the rapid increase of genomic data, main attention of microbial ecology research shifted from cultivation-oriented studies towards metagenomic studies. Despite these efforts, the direct link between the molecular properties and the measurable changes in the functional performance of the ecosystem is often poorly documented. A quantitative understanding of functional properties in relation to the molecular changes requires effective integration, standardization, and parallelization of experiments. High-resolution functional characterization is a prerequisite for interpretation of changes in metagenomic properties, and will improve our understanding of microbial communities and facilitate their exploration for health and circular economy related objectives.
AB - Natural microbial communities are composed of a large diversity of interacting microorganisms, each with a specific role in the functional properties of the ecosystem. The objectives in microbial ecology research are related to identifying, understanding and exploring the role of these different microorganisms. Because of the rapidly increasing power of DNA sequencing and the rapid increase of genomic data, main attention of microbial ecology research shifted from cultivation-oriented studies towards metagenomic studies. Despite these efforts, the direct link between the molecular properties and the measurable changes in the functional performance of the ecosystem is often poorly documented. A quantitative understanding of functional properties in relation to the molecular changes requires effective integration, standardization, and parallelization of experiments. High-resolution functional characterization is a prerequisite for interpretation of changes in metagenomic properties, and will improve our understanding of microbial communities and facilitate their exploration for health and circular economy related objectives.
U2 - 10.1016/j.copbio.2021.01.017
DO - 10.1016/j.copbio.2021.01.017
M3 - Article
AN - SCOPUS:85100802164
SN - 0958-1669
VL - 67
SP - 158
EP - 165
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
ER -
