TY - JOUR
T1 - Experimental challenge models for Johne's disease: a review and proposed international guidelines
AU - Hines, M.E.
AU - Stabel, J.R.
AU - Sweeney, R.W.
AU - Griffin, F.
AU - Talaat, A.M.
AU - Bakker, D.
AU - Benedictus, G.
AU - Davis, W.C.
AU - de Lisle, G.W.
AU - Gardner, I.A.
AU - Juste, R.A.
AU - Kapur, V.
AU - Koets, A.
AU - McNair, J.
AU - Pruitt, G.
AU - Whitlock, R.H.
N1 - 000247363200001
PY - 2007
Y1 - 2007
N2 - An international committee of Johne's disease (JD) researchers was convened to develop guidelines for JD challenge studies in multiple animal species. The intent was to develop and propose international standard guidelines for models based on animal species that would gain acceptance worldwide. Parameters essential for the development of long-term and short-term infection models were outlined and harmonized to provide a ¿best fit¿ JD challenge model for cattle, goats, sheep, cervids, and mice. These models will be useful to study host¿pathogen interactions, host immunity at the local and systemic level, and for evaluating vaccine candidates and therapeutics. The consensus guidelines herein list by animal species strains of Mycobacterium avium subsp. paratuberculosis used, challenge dose, dose frequency, age of challenge, route of challenge, preparation of inoculum, experimental animal selection, quality control, minimal experimental endpoints and other parameters.
AB - An international committee of Johne's disease (JD) researchers was convened to develop guidelines for JD challenge studies in multiple animal species. The intent was to develop and propose international standard guidelines for models based on animal species that would gain acceptance worldwide. Parameters essential for the development of long-term and short-term infection models were outlined and harmonized to provide a ¿best fit¿ JD challenge model for cattle, goats, sheep, cervids, and mice. These models will be useful to study host¿pathogen interactions, host immunity at the local and systemic level, and for evaluating vaccine candidates and therapeutics. The consensus guidelines herein list by animal species strains of Mycobacterium avium subsp. paratuberculosis used, challenge dose, dose frequency, age of challenge, route of challenge, preparation of inoculum, experimental animal selection, quality control, minimal experimental endpoints and other parameters.
KW - avium subsp paratuberculosis
KW - swiss white mice
KW - deer cervus-elaphus
KW - experimental para-tuberculosis
KW - experimental-infection model
KW - experimental oral infection
KW - linked-immunosorbent-assay
KW - american wild ruminants
KW - small-intestinal mucosa
KW - mycobacterium-avi
U2 - 10.1016/j.vetmic.2007.03.009
DO - 10.1016/j.vetmic.2007.03.009
M3 - Article
SN - 0378-1135
VL - 122
SP - 197
EP - 222
JO - Veterinary Microbiology
JF - Veterinary Microbiology
IS - 39541
ER -
