Evolutionary Mechanisms Involved in Development of Fungal Secondary Metabolite Gene Clusters

Geromy G. Moore*, Jérôme Collemare, Marc Henri Lebrun, Rosie E. Bradshaw

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

5 Citations (Scopus)


Extensive adaptability and diversity in fungi, even among closely related species, enable them to occupy various ecological niches. Of particular importance for niche adaptation is the production of fungal secondary metabolites (SM) because they can offer a distinct selective advantage in specific environments. This chapter explores two examples of SM clusters: aflatoxin-like gene clusters in fungi such as Aspergillus flavus and ACE1 gene clusters that were originally described in Magnaporthe oryzae. Both clusters occur in different classes of fungi, and a heterogeneous collection of gene clusters in related and more distant fungal taxa can help explain the evolutionary processes that led to their formation, maintenance, and inactivation/loss. Together, they illustrate the interplay of recombination and horizontal gene transfer (HGT), as well as other genomic modifications that can impact SM biosynthetic pathways in fungi. This edition first published 2014

Original languageEnglish
Title of host publicationNatural Products
Subtitle of host publicationDiscourse, Diversity, and Design
EditorsA. Osbourn, R.J. Goss, G.T. Carter
Number of pages16
ISBN (Electronic)9781118794623
ISBN (Print)9781118298060
Publication statusPublished - 5 May 2014


  • ACE1 gene clusters
  • Aspergillus flavus
  • Biosynthetic pathways
  • Evolutionary mechanisms
  • Fungal secondary metabolites (SM) gene clusters
  • Horizontal gene transfer (HGT)


Dive into the research topics of 'Evolutionary Mechanisms Involved in Development of Fungal Secondary Metabolite Gene Clusters'. Together they form a unique fingerprint.

Cite this