Evolutionary Mechanisms Involved in Development of Fungal Secondary Metabolite Gene Clusters

Geromy G. Moore; Jérôme Collemare; Marc Henri Lebrun; Rosie E. Bradshaw

doi:10.1002/9781118794623.ch18

Evolutionary Mechanisms Involved in Development of Fungal Secondary Metabolite Gene Clusters

Geromy G. Moore^*, Jérôme Collemare, Marc Henri Lebrun, Rosie E. Bradshaw

^*Corresponding author for this work

Laboratory of Phytopathology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

8 Citations (Scopus)

Abstract

Extensive adaptability and diversity in fungi, even among closely related species, enable them to occupy various ecological niches. Of particular importance for niche adaptation is the production of fungal secondary metabolites (SM) because they can offer a distinct selective advantage in specific environments. This chapter explores two examples of SM clusters: aflatoxin-like gene clusters in fungi such as Aspergillus flavus and ACE1 gene clusters that were originally described in Magnaporthe oryzae. Both clusters occur in different classes of fungi, and a heterogeneous collection of gene clusters in related and more distant fungal taxa can help explain the evolutionary processes that led to their formation, maintenance, and inactivation/loss. Together, they illustrate the interplay of recombination and horizontal gene transfer (HGT), as well as other genomic modifications that can impact SM biosynthetic pathways in fungi. This edition first published 2014

Original language	English
Title of host publication	Natural Products
Subtitle of host publication	Discourse, Diversity, and Design
Editors	A. Osbourn, R.J. Goss, G.T. Carter
Publisher	Wiley
Chapter	18
Pages	341-356
Number of pages	16
ISBN (Electronic)	9781118794623
ISBN (Print)	9781118298060
DOIs	https://doi.org/10.1002/9781118794623.ch18
Publication status	Published - 5 May 2014

Keywords

ACE1 gene clusters
Aspergillus flavus
Biosynthetic pathways
Evolutionary mechanisms
Fungal secondary metabolites (SM) gene clusters
Horizontal gene transfer (HGT)

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10.1002/9781118794623.ch18

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abstract = "Extensive adaptability and diversity in fungi, even among closely related species, enable them to occupy various ecological niches. Of particular importance for niche adaptation is the production of fungal secondary metabolites (SM) because they can offer a distinct selective advantage in specific environments. This chapter explores two examples of SM clusters: aflatoxin-like gene clusters in fungi such as Aspergillus flavus and ACE1 gene clusters that were originally described in Magnaporthe oryzae. Both clusters occur in different classes of fungi, and a heterogeneous collection of gene clusters in related and more distant fungal taxa can help explain the evolutionary processes that led to their formation, maintenance, and inactivation/loss. Together, they illustrate the interplay of recombination and horizontal gene transfer (HGT), as well as other genomic modifications that can impact SM biosynthetic pathways in fungi. This edition first published 2014",

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Evolutionary Mechanisms Involved in Development of Fungal Secondary Metabolite Gene Clusters. / Moore, Geromy G.; Collemare, Jérôme; Lebrun, Marc Henri et al.
Natural Products: Discourse, Diversity, and Design. ed. / A. Osbourn; R.J. Goss; G.T. Carter. Wiley, 2014. p. 341-356.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

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AU - Lebrun, Marc Henri

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AB - Extensive adaptability and diversity in fungi, even among closely related species, enable them to occupy various ecological niches. Of particular importance for niche adaptation is the production of fungal secondary metabolites (SM) because they can offer a distinct selective advantage in specific environments. This chapter explores two examples of SM clusters: aflatoxin-like gene clusters in fungi such as Aspergillus flavus and ACE1 gene clusters that were originally described in Magnaporthe oryzae. Both clusters occur in different classes of fungi, and a heterogeneous collection of gene clusters in related and more distant fungal taxa can help explain the evolutionary processes that led to their formation, maintenance, and inactivation/loss. Together, they illustrate the interplay of recombination and horizontal gene transfer (HGT), as well as other genomic modifications that can impact SM biosynthetic pathways in fungi. This edition first published 2014

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KW - Biosynthetic pathways

KW - Evolutionary mechanisms

KW - Fungal secondary metabolites (SM) gene clusters

KW - Horizontal gene transfer (HGT)

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SN - 9781118298060

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EP - 356

BT - Natural Products

A2 - Osbourn, A.

A2 - Goss, R.J.

A2 - Carter, G.T.

PB - Wiley

ER -

Evolutionary Mechanisms Involved in Development of Fungal Secondary Metabolite Gene Clusters

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Keywords

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