Evidence for recombination among the alleles encoding TEM and SHV ß-lactamases

M. Barlow, J. Fatollahi, M.L.M. Salverda

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Abstract

Objectives: The objective of this research was to determine whether recombination occurs in class A ß-lactamases. Methods: We performed 2 analysis of the observed and expected numbers of times that ß-lactamases from the TEM, SHV and CTX-M groups co-occurred. Additionally, we performed phylogenetic analysis to detect independent occurrences of silent mutations in blaTEM and blaSHV variants. Results: We found that the distribution of co-occurring blaTEM, blaSHV and blaCTX-M alleles in clinical microbial populations is consistent with the regular occurrence of recombination among alleles within the groups. We also found that the distribution of silent mutations in blaTEM and blaSHV alleles is inconsistent with spontaneous point mutations. Conclusions: Our findings indicate that recombination has an important effect on the sequence evolution and population distribution of the alleles that encode class A ß-lactamases
Original languageEnglish
Pages (from-to)256-259
JournalJournal of Antimicrobial Chemotherapy
Volume63
Issue number2
DOIs
Publication statusPublished - 2009

Keywords

  • hong-kong
  • spectrum
  • enterobacteriaceae
  • populations
  • selection
  • evolution
  • strains

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