Equivalence testing using existing reference data: An example with genetically modified and conventional crops in animal feeding studies

Hilko van der Voet*, Paul W. Goedhart, Kerstin Schmidt

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

An equivalence testing method is described to assess the safety of regulated products using relevant data obtained in historical studies with assumedly safe reference products. The method is illustrated using data from a series of animal feeding studies with genetically modified and reference maize varieties. Several criteria for quantifying equivalence are discussed, and study-corrected distribution-wise equivalence is selected as being appropriate for the example case study. An equivalence test is proposed based on a high probability of declaring equivalence in a simplified situation, where there is no between-group variation, where the historical and current studies have the same residual variance, and where the current study is assumed to have a sample size as set by a regulator. The method makes use of generalized fiducial inference methods to integrate uncertainties from both the historical and the current data.
Original languageEnglish
Pages (from-to)472-485
JournalFood and Chemical Toxicology
Volume109
DOIs
Publication statusPublished - 2017

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