Enzymatic synthesis and characterization of novel terpolymers from renewable sources

Diana Aparaschivei, Anamaria Todea*, August E. Frissen, Valentin Badea, Gerlinde Rusu, Eugen Sisu, Maria Puiu, Carmen G. Boeriu, Francisc Peter

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


2,5-Furandicarboxylic acid and itaconic acid are both important biobased platform chemicals and their terpolymer with 1,6-hexanediol (HDO) can be the starting point for a new class of reactive polyesters, with important applications. The green synthetic route developed in this study involves a biocatalytic condensation polymerization reaction of dimethyl furan-2,5-dicarboxylate (DMFDC) and dimethyl itaconate (DMI) with HDO in toluene at 80°C, using commercial immobilized lipases from Candida antarctica B. In the best conditions, the formed polymer product was isolated with more than 80% yield, containing about 85% terpolymer with average molecular mass of about 1200 (Mn, calculated from MALDI-TOF MS data) and 15% DMFDC-HDO copolymer. Considering the higher reactivity of DMFDC, the composition of the synthesized polymer can be directed by adjusting the molar ratio of DMFDC and DMI, as well as by extending the reaction time. Structural analysis by NMR demonstrated the regioselective preference for the carbonyl group from DMI adjacent to the methylene group. The biocatalyst was successfully reused in multiple reaction cycles.

Original languageEnglish
JournalPure and Applied Chemistry
Issue number3
Early online date22 Nov 2018
Publication statusPublished - 22 Nov 2018


  • biobased terpolymer
  • biocatalysis
  • dimethyl furan-2,5-dicarboxylate
  • dimethyl itaconate
  • lipase
  • POC-2018

Fingerprint Dive into the research topics of 'Enzymatic synthesis and characterization of novel terpolymers from renewable sources'. Together they form a unique fingerprint.

  • Cite this