Environmental Signals Influencing Myeloid Cell Metabolism and Function in Diabetes

Jacqueline M. Ratter, Cees J. Tack, Mihai G. Netea, Rinke Stienstra*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Abstract

The environment induces metabolic reprogramming of immune cells via specific signaling pathways. Recent studies have revealed that changes in cell metabolism affect key immune cell functions including cytokine production and migration. In diabetes, these functions are either insufficiently or excessively activated, translating into diabetes-associated complications, including increased susceptibility to infection and accelerated cardiovascular disease. Diabetes alters the abundance of environmental signals, including glucose, insulin, and lipids. Subsequently, changes in environmental signals drive metabolic reprogramming, impair immune cell function, and ultimately contribute to diabetes-associated complications. We review here recent studies on changes in innate immune cell metabolism, especially in myeloid cells, that are driven by environmental signals relevant to diabetes, and discuss therapeutic perspectives of targeting metabolism of immune cells in diabetes.

Original languageEnglish
Pages (from-to)468-480
JournalTrends in Endocrinology and Metabolism
Volume29
Issue number7
Early online date19 May 2018
DOIs
Publication statusPublished - Jul 2018

Keywords

  • diabetes
  • immunometabolism
  • inflammation
  • macrophages

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