Enrichment of nucleic acids

Haim Bau (Inventor), Jinzhao Song (Inventor), Changchun Liu (Inventor), Michael Mauk (Inventor), J. van der Oost (Inventor), J.W. Hegge (Inventor)

Research output: PatentOther research output


Provided are methods directed to enriching nucleic acids in a biological sample. These methods, in some embodiments can discriminately enrich the abundance of low-copy nucleic acids relative to higher-copy nucleic acids. In some embodiments, the methods provided can enrich a low-copy number mutant allele associated with a disease state, thus allowing early detection and optimized treatment. In other embodiments, the methods can be used for detection of particular molecules, such as antigens, in a sample.
Original languageEnglish
Patent numberWO2019178346
Priority date14/03/18
Publication statusPublished - 19 Sep 2019


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