Provided are methods directed to enriching nucleic acids in a biological sample. These methods, in some embodiments can discriminately enrich the abundance of low-copy nucleic acids relative to higher-copy nucleic acids. In some embodiments, the methods provided can enrich a low-copy number mutant allele associated with a disease state, thus allowing early detection and optimized treatment. In other embodiments, the methods can be used for detection of particular molecules, such as antigens, in a sample.
|Publication status||Published - 19 Sep 2019|
Bau, H., Song, J., Liu, C., Mauk, M., van der Oost, J., & Hegge, J. W. (2019). Enrichment of nucleic acids. (Patent No. WO2019178346). https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=WO&NR=2019178346A1&KC=A1&FT=D&ND=3&date=20190919&DB=&locale=en_EP#