Enrichment of nucleic acids

Haim Bau; Jinzhao Song; Changchun Liu; Michael Mauk; J. van der Oost; J.W. Hegge

Enrichment of nucleic acids

Haim Bau (Inventor), Jinzhao Song (Inventor), Changchun Liu (Inventor), Michael Mauk (Inventor), J. van der Oost (Inventor), J.W. Hegge (Inventor)

Research output: Patent

Abstract

Provided are methods directed to enriching nucleic acids in a biological sample. These methods, in some embodiments can discriminately enrich the abundance of low-copy nucleic acids relative to higher-copy nucleic acids. In some embodiments, the methods provided can enrich a low-copy number mutant allele associated with a disease state, thus allowing early detection and optimized treatment. In other embodiments, the methods can be used for detection of particular molecules, such as antigens, in a sample.

Original language	English
Patent number	WO2019178346
Priority date	14/03/18
Publication status	Published - 19 Sept 2019

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title = "Enrichment of nucleic acids",

abstract = "Provided are methods directed to enriching nucleic acids in a biological sample. These methods, in some embodiments can discriminately enrich the abundance of low-copy nucleic acids relative to higher-copy nucleic acids. In some embodiments, the methods provided can enrich a low-copy number mutant allele associated with a disease state, thus allowing early detection and optimized treatment. In other embodiments, the methods can be used for detection of particular molecules, such as antigens, in a sample.",

author = "Haim Bau and Jinzhao Song and Changchun Liu and Michael Mauk and {van der Oost}, J. and J.W. Hegge",

year = "2019",

month = sep,

day = "19",

language = "English",

type = "Patent",

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TY - PAT

T1 - Enrichment of nucleic acids

AU - Bau, Haim

AU - Song, Jinzhao

AU - Liu, Changchun

AU - Mauk, Michael

AU - van der Oost, J.

AU - Hegge, J.W.

PY - 2019/9/19

Y1 - 2019/9/19

N2 - Provided are methods directed to enriching nucleic acids in a biological sample. These methods, in some embodiments can discriminately enrich the abundance of low-copy nucleic acids relative to higher-copy nucleic acids. In some embodiments, the methods provided can enrich a low-copy number mutant allele associated with a disease state, thus allowing early detection and optimized treatment. In other embodiments, the methods can be used for detection of particular molecules, such as antigens, in a sample.

AB - Provided are methods directed to enriching nucleic acids in a biological sample. These methods, in some embodiments can discriminately enrich the abundance of low-copy nucleic acids relative to higher-copy nucleic acids. In some embodiments, the methods provided can enrich a low-copy number mutant allele associated with a disease state, thus allowing early detection and optimized treatment. In other embodiments, the methods can be used for detection of particular molecules, such as antigens, in a sample.

M3 - Patent

M1 - WO2019178346

ER -

Enrichment of nucleic acids

Abstract

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