Enrichment of nucleic acids

Haim Bau (Inventor), Jinzhao Song (Inventor), Changchun Liu (Inventor), Michael Mauk (Inventor), J. van der Oost (Inventor), J.W. Hegge (Inventor)

Research output: PatentOther research output

Abstract

Provided are methods directed to enriching nucleic acids in a biological sample. These methods, in some embodiments can discriminately enrich the abundance of low-copy nucleic acids relative to higher-copy nucleic acids. In some embodiments, the methods provided can enrich a low-copy number mutant allele associated with a disease state, thus allowing early detection and optimized treatment. In other embodiments, the methods can be used for detection of particular molecules, such as antigens, in a sample.
Original languageEnglish
Patent numberWO2019178346
Priority date14/03/18
Publication statusPublished - 19 Sep 2019

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Nucleic Acids
Antigens
Molecules

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Bau, H., Song, J., Liu, C., Mauk, M., van der Oost, J., & Hegge, J. W. (2019). Enrichment of nucleic acids. (Patent No. WO2019178346).
Bau, Haim (Inventor) ; Song, Jinzhao (Inventor) ; Liu, Changchun (Inventor) ; Mauk, Michael (Inventor) ; van der Oost, J. (Inventor) ; Hegge, J.W. (Inventor). / Enrichment of nucleic acids. Patent No.: WO2019178346.
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title = "Enrichment of nucleic acids",
abstract = "Provided are methods directed to enriching nucleic acids in a biological sample. These methods, in some embodiments can discriminately enrich the abundance of low-copy nucleic acids relative to higher-copy nucleic acids. In some embodiments, the methods provided can enrich a low-copy number mutant allele associated with a disease state, thus allowing early detection and optimized treatment. In other embodiments, the methods can be used for detection of particular molecules, such as antigens, in a sample.",
author = "Haim Bau and Jinzhao Song and Changchun Liu and Michael Mauk and {van der Oost}, J. and J.W. Hegge",
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Bau, H, Song, J, Liu, C, Mauk, M, van der Oost, J & Hegge, JW 2019, Enrichment of nucleic acids, Patent No. WO2019178346.

Enrichment of nucleic acids. / Bau, Haim (Inventor); Song, Jinzhao (Inventor); Liu, Changchun (Inventor); Mauk, Michael (Inventor); van der Oost, J. (Inventor); Hegge, J.W. (Inventor).

Patent No.: WO2019178346.

Research output: PatentOther research output

TY - PAT

T1 - Enrichment of nucleic acids

AU - Bau, Haim

AU - Song, Jinzhao

AU - Liu, Changchun

AU - Mauk, Michael

AU - van der Oost, J.

AU - Hegge, J.W.

PY - 2019/9/19

Y1 - 2019/9/19

N2 - Provided are methods directed to enriching nucleic acids in a biological sample. These methods, in some embodiments can discriminately enrich the abundance of low-copy nucleic acids relative to higher-copy nucleic acids. In some embodiments, the methods provided can enrich a low-copy number mutant allele associated with a disease state, thus allowing early detection and optimized treatment. In other embodiments, the methods can be used for detection of particular molecules, such as antigens, in a sample.

AB - Provided are methods directed to enriching nucleic acids in a biological sample. These methods, in some embodiments can discriminately enrich the abundance of low-copy nucleic acids relative to higher-copy nucleic acids. In some embodiments, the methods provided can enrich a low-copy number mutant allele associated with a disease state, thus allowing early detection and optimized treatment. In other embodiments, the methods can be used for detection of particular molecules, such as antigens, in a sample.

M3 - Patent

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Bau H, Song J, Liu C, Mauk M, van der Oost J, Hegge JW, inventors. Enrichment of nucleic acids. WO2019178346. 2019 Sep 19.