Enhancing vector refractoriness to trypanosome infection: achievements, challenges and perspectives

Henry M. Kariithi; Irene K. Meki; Daniela I. Schneider; Linda De Vooght; Fathiya M. Khamis; Anne Geiger; Guler Demirbaş-Uzel; Just M. Vlak; Ikbal Agah iNCE; Sorge Kelm; Flobert Njiokou; Florence N. Wamwiri; Imna I. Malele; Brian L. Weiss; Adly M.M. Abd-Alla

doi:10.1186/s12866-018-1280-y

Enhancing vector refractoriness to trypanosome infection: achievements, challenges and perspectives

Henry M. Kariithi, Irene K. Meki, Daniela I. Schneider, Linda De Vooght, Fathiya M. Khamis, Anne Geiger, Guler Demirbaş-Uzel, Just M. Vlak, Ikbal Agah iNCE, Sorge Kelm, Flobert Njiokou, Florence N. Wamwiri, Imna I. Malele, Brian L. Weiss, Adly M.M. Abd-Alla^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

15 Citations (Scopus)

Abstract

With the absence of effective prophylactic vaccines and drugs against African trypanosomosis, control of this group of zoonotic neglected tropical diseases depends the control of the tsetse fly vector. When applied in an area-wide insect pest management approach, the sterile insect technique (SIT) is effective in eliminating single tsetse species from isolated populations. The need to enhance the effectiveness of SIT led to the concept of investigating tsetse-trypanosome interactions by a consortium of researchers in a five-year (2013-2018) Coordinated Research Project (CRP) organized by the Joint Division of FAO/IAEA. The goal of this CRP was to elucidate tsetse-symbiome-pathogen molecular interactions to improve SIT and SIT-compatible interventions for trypanosomoses control by enhancing vector refractoriness. This would allow extension of SIT into areas with potential disease transmission. This paper highlights the CRP's major achievements and discusses the science-based perspectives for successful mitigation or eradication of African trypanosomosis.

Original language	English
Article number	179
Journal	BMC Microbiology
Volume	18
DOIs	https://doi.org/10.1186/s12866-018-1280-y
Publication status	Published - 23 Nov 2018

Keywords

Glossina
Hytrosaviridae
Microbiota
Paratransgenesis
Trypanosoma-refractoriness, sterile insect technique
Vector competence

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/s12866-018-1280-yLicence: CC BY

Cite this

Kariithi, H. M., Meki, I. K., Schneider, D. I., De Vooght, L., Khamis, F. M., Geiger, A., Demirbaş-Uzel, G., Vlak, J. M., iNCE, I. A., Kelm, S., Njiokou, F., Wamwiri, F. N., Malele, I. I., Weiss, B. L., & Abd-Alla, A. M. M. (2018). Enhancing vector refractoriness to trypanosome infection: achievements, challenges and perspectives. BMC Microbiology, 18, Article 179. https://doi.org/10.1186/s12866-018-1280-y

@article{b7ffd5d2cec94a6cb6366e684403e3b9,

title = "Enhancing vector refractoriness to trypanosome infection: achievements, challenges and perspectives",

abstract = "With the absence of effective prophylactic vaccines and drugs against African trypanosomosis, control of this group of zoonotic neglected tropical diseases depends the control of the tsetse fly vector. When applied in an area-wide insect pest management approach, the sterile insect technique (SIT) is effective in eliminating single tsetse species from isolated populations. The need to enhance the effectiveness of SIT led to the concept of investigating tsetse-trypanosome interactions by a consortium of researchers in a five-year (2013-2018) Coordinated Research Project (CRP) organized by the Joint Division of FAO/IAEA. The goal of this CRP was to elucidate tsetse-symbiome-pathogen molecular interactions to improve SIT and SIT-compatible interventions for trypanosomoses control by enhancing vector refractoriness. This would allow extension of SIT into areas with potential disease transmission. This paper highlights the CRP's major achievements and discusses the science-based perspectives for successful mitigation or eradication of African trypanosomosis.",

keywords = "Glossina, Hytrosaviridae, Microbiota, Paratransgenesis, Trypanosoma-refractoriness, sterile insect technique, Vector competence",

author = "Kariithi, {Henry M.} and Meki, {Irene K.} and Schneider, {Daniela I.} and {De Vooght}, Linda and Khamis, {Fathiya M.} and Anne Geiger and Guler Demirba{\c s}-Uzel and Vlak, {Just M.} and iNCE, {Ikbal Agah} and Sorge Kelm and Flobert Njiokou and Wamwiri, {Florence N.} and Malele, {Imna I.} and Weiss, {Brian L.} and Abd-Alla, {Adly M.M.}",

year = "2018",

month = nov,

day = "23",

doi = "10.1186/s12866-018-1280-y",

language = "English",

volume = "18",

journal = "BMC Microbiology",

issn = "1471-2180",

publisher = "BioMed Central",

}

TY - JOUR

T1 - Enhancing vector refractoriness to trypanosome infection

T2 - achievements, challenges and perspectives

AU - Kariithi, Henry M.

AU - Meki, Irene K.

AU - Schneider, Daniela I.

AU - De Vooght, Linda

AU - Khamis, Fathiya M.

AU - Geiger, Anne

AU - Demirbaş-Uzel, Guler

AU - Vlak, Just M.

AU - iNCE, Ikbal Agah

AU - Kelm, Sorge

AU - Njiokou, Flobert

AU - Wamwiri, Florence N.

AU - Malele, Imna I.

AU - Weiss, Brian L.

AU - Abd-Alla, Adly M.M.

PY - 2018/11/23

Y1 - 2018/11/23

N2 - With the absence of effective prophylactic vaccines and drugs against African trypanosomosis, control of this group of zoonotic neglected tropical diseases depends the control of the tsetse fly vector. When applied in an area-wide insect pest management approach, the sterile insect technique (SIT) is effective in eliminating single tsetse species from isolated populations. The need to enhance the effectiveness of SIT led to the concept of investigating tsetse-trypanosome interactions by a consortium of researchers in a five-year (2013-2018) Coordinated Research Project (CRP) organized by the Joint Division of FAO/IAEA. The goal of this CRP was to elucidate tsetse-symbiome-pathogen molecular interactions to improve SIT and SIT-compatible interventions for trypanosomoses control by enhancing vector refractoriness. This would allow extension of SIT into areas with potential disease transmission. This paper highlights the CRP's major achievements and discusses the science-based perspectives for successful mitigation or eradication of African trypanosomosis.

AB - With the absence of effective prophylactic vaccines and drugs against African trypanosomosis, control of this group of zoonotic neglected tropical diseases depends the control of the tsetse fly vector. When applied in an area-wide insect pest management approach, the sterile insect technique (SIT) is effective in eliminating single tsetse species from isolated populations. The need to enhance the effectiveness of SIT led to the concept of investigating tsetse-trypanosome interactions by a consortium of researchers in a five-year (2013-2018) Coordinated Research Project (CRP) organized by the Joint Division of FAO/IAEA. The goal of this CRP was to elucidate tsetse-symbiome-pathogen molecular interactions to improve SIT and SIT-compatible interventions for trypanosomoses control by enhancing vector refractoriness. This would allow extension of SIT into areas with potential disease transmission. This paper highlights the CRP's major achievements and discusses the science-based perspectives for successful mitigation or eradication of African trypanosomosis.

KW - Glossina

KW - Hytrosaviridae

KW - Microbiota

KW - Paratransgenesis

KW - Trypanosoma-refractoriness, sterile insect technique

KW - Vector competence

U2 - 10.1186/s12866-018-1280-y

DO - 10.1186/s12866-018-1280-y

M3 - Article

C2 - 30470182

AN - SCOPUS:85057076295

SN - 1471-2180

VL - 18

JO - BMC Microbiology

JF - BMC Microbiology

M1 - 179

ER -

Enhancing vector refractoriness to trypanosome infection: achievements, challenges and perspectives

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this