Enhancing vector refractoriness to trypanosome infection: achievements, challenges and perspectives

Henry M. Kariithi; Irene K. Meki; Daniela I. Schneider; Linda De Vooght; Fathiya M. Khamis; Anne Geiger; Guler Demirbaş-Uzel; Just M. Vlak; Ikbal Agah iNCE; Sorge Kelm; Flobert Njiokou; Florence N. Wamwiri; Imna I. Malele; Brian L. Weiss; Adly M.M. Abd-Alla

doi:10.1186/s12866-018-1280-y

Enhancing vector refractoriness to trypanosome infection: achievements, challenges and perspectives

Henry M. Kariithi, Irene K. Meki, Daniela I. Schneider, Linda De Vooght, Fathiya M. Khamis, Anne Geiger, Guler Demirbaş-Uzel, Just M. Vlak, Ikbal Agah iNCE, Sorge Kelm, Flobert Njiokou, Florence N. Wamwiri, Imna I. Malele, Brian L. Weiss, Adly M.M. Abd-Alla^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

Abstract

With the absence of effective prophylactic vaccines and drugs against African trypanosomosis, control of this group of zoonotic neglected tropical diseases depends the control of the tsetse fly vector. When applied in an area-wide insect pest management approach, the sterile insect technique (SIT) is effective in eliminating single tsetse species from isolated populations. The need to enhance the effectiveness of SIT led to the concept of investigating tsetse-trypanosome interactions by a consortium of researchers in a five-year (2013-2018) Coordinated Research Project (CRP) organized by the Joint Division of FAO/IAEA. The goal of this CRP was to elucidate tsetse-symbiome-pathogen molecular interactions to improve SIT and SIT-compatible interventions for trypanosomoses control by enhancing vector refractoriness. This would allow extension of SIT into areas with potential disease transmission. This paper highlights the CRP's major achievements and discusses the science-based perspectives for successful mitigation or eradication of African trypanosomosis.

Original language	English
Article number	179
Journal	BMC Microbiology
Volume	18
DOIs	https://doi.org/10.1186/s12866-018-1280-y
Publication status	Published - 23 Nov 2018

Keywords

Glossina
Hytrosaviridae
Microbiota
Paratransgenesis
Trypanosoma-refractoriness, sterile insect technique
Vector competence

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Kariithi, H. M., Meki, I. K., Schneider, D. I., De Vooght, L., Khamis, F. M., Geiger, A., Demirbaş-Uzel, G., Vlak, J. M., iNCE, I. A., Kelm, S., Njiokou, F., Wamwiri, F. N., Malele, I. I., Weiss, B. L., & Abd-Alla, A. M. M. (2018). Enhancing vector refractoriness to trypanosome infection: achievements, challenges and perspectives. BMC Microbiology, 18, [179]. https://doi.org/10.1186/s12866-018-1280-y

Kariithi, Henry M. ; Meki, Irene K. ; Schneider, Daniela I. ; De Vooght, Linda ; Khamis, Fathiya M. ; Geiger, Anne ; Demirbaş-Uzel, Guler ; Vlak, Just M. ; iNCE, Ikbal Agah ; Kelm, Sorge ; Njiokou, Flobert ; Wamwiri, Florence N. ; Malele, Imna I. ; Weiss, Brian L. ; Abd-Alla, Adly M.M. / Enhancing vector refractoriness to trypanosome infection : achievements, challenges and perspectives. In: BMC Microbiology. 2018 ; Vol. 18.

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Enhancing vector refractoriness to trypanosome infection : achievements, challenges and perspectives. / Kariithi, Henry M.; Meki, Irene K.; Schneider, Daniela I.; De Vooght, Linda; Khamis, Fathiya M.; Geiger, Anne; Demirbaş-Uzel, Guler; Vlak, Just M.; iNCE, Ikbal Agah; Kelm, Sorge; Njiokou, Flobert; Wamwiri, Florence N.; Malele, Imna I.; Weiss, Brian L.; Abd-Alla, Adly M.M.

In: BMC Microbiology, Vol. 18, 179, 23.11.2018.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Kariithi, Henry M.

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AU - Khamis, Fathiya M.

AU - Geiger, Anne

AU - Demirbaş-Uzel, Guler

AU - Vlak, Just M.

AU - iNCE, Ikbal Agah

AU - Kelm, Sorge

AU - Njiokou, Flobert

AU - Wamwiri, Florence N.

AU - Malele, Imna I.

AU - Weiss, Brian L.

AU - Abd-Alla, Adly M.M.

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N2 - With the absence of effective prophylactic vaccines and drugs against African trypanosomosis, control of this group of zoonotic neglected tropical diseases depends the control of the tsetse fly vector. When applied in an area-wide insect pest management approach, the sterile insect technique (SIT) is effective in eliminating single tsetse species from isolated populations. The need to enhance the effectiveness of SIT led to the concept of investigating tsetse-trypanosome interactions by a consortium of researchers in a five-year (2013-2018) Coordinated Research Project (CRP) organized by the Joint Division of FAO/IAEA. The goal of this CRP was to elucidate tsetse-symbiome-pathogen molecular interactions to improve SIT and SIT-compatible interventions for trypanosomoses control by enhancing vector refractoriness. This would allow extension of SIT into areas with potential disease transmission. This paper highlights the CRP's major achievements and discusses the science-based perspectives for successful mitigation or eradication of African trypanosomosis.

AB - With the absence of effective prophylactic vaccines and drugs against African trypanosomosis, control of this group of zoonotic neglected tropical diseases depends the control of the tsetse fly vector. When applied in an area-wide insect pest management approach, the sterile insect technique (SIT) is effective in eliminating single tsetse species from isolated populations. The need to enhance the effectiveness of SIT led to the concept of investigating tsetse-trypanosome interactions by a consortium of researchers in a five-year (2013-2018) Coordinated Research Project (CRP) organized by the Joint Division of FAO/IAEA. The goal of this CRP was to elucidate tsetse-symbiome-pathogen molecular interactions to improve SIT and SIT-compatible interventions for trypanosomoses control by enhancing vector refractoriness. This would allow extension of SIT into areas with potential disease transmission. This paper highlights the CRP's major achievements and discusses the science-based perspectives for successful mitigation or eradication of African trypanosomosis.

KW - Glossina

KW - Hytrosaviridae

KW - Microbiota

KW - Paratransgenesis

KW - Trypanosoma-refractoriness, sterile insect technique

KW - Vector competence

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DO - 10.1186/s12866-018-1280-y

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