Endotoxin and particulate matter emitted by livestock farms and respiratory health effects in neighboring residents

Myrna M.T. de Rooij, Lidwien A.M. Smit, Hans J. Erbrink, Thomas J. Hagenaars, Gerard Hoek, Nico W.M. Ogink, Albert Winkel, Dick J.J. Heederik, Inge M. Wouters

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Living in livestock-dense areas has been associated with health effects, suggesting airborne exposures to livestock farm emissions to be relevant for public health. Livestock farm emissions involve complex mixtures of various gases and particles. Endotoxin, a pro-inflammatory agent of microbial origin, is a constituent of livestock farm emitted particulate matter (PM) that is potentially related to the observed health effects. Quantification of livestock associated endotoxin exposure at residential addresses in relation to health outcomes has not been performed earlier. Objectives: We aimed to assess exposure-response relations for a range of respiratory endpoints and atopic sensitization in relation to livestock farm associated PM10 and endotoxin levels. Methods: Self-reported respiratory symptoms of 12,117 persons participating in a population-based cross-sectional study were analyzed. For 2494 persons, data on lung function (spirometry) and serologically assessed atopic sensitization was additionally available. Annual-average PM10 and endotoxin concentrations at home addresses were predicted by dispersion modelling and land-use regression (LUR) modelling. Exposure-response relations were analyzed with generalized additive models. Results: Health outcomes were generally more strongly associated with exposure to livestock farm emitted endotoxin compared to PM10. An inverse association was observed for dispersion modelled exposure with atopic sensitization (endotoxin: p =.004, PM10: p =.07) and asthma (endotoxin: p =.029, PM10: p =.022). Prevalence of respiratory symptoms decreased with increasing endotoxin concentration at the lower range, while at the higher range prevalence increased with increasing concentration (p <.05). Associations between lung function parameters with exposure to PM10 and endotoxin were not statistically significant (p >.05). Conclusions: Exposure to livestock farm emitted particulate matter is associated with respiratory health effects and atopic sensitization in non-farming residents. Results indicate endotoxin to be a potentially plausible etiologic agent, suggesting non-infectious aspects of microbial emissions from livestock farms to be important with respect to public health.

Original languageEnglish
Article number105009
JournalEnvironment International
Volume132
DOIs
Publication statusPublished - 1 Nov 2019

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particulate matter
livestock
farm
public health
effect
health
asthma
exposure
modeling
land use
gas

Keywords

  • Air pollution
  • Emissions
  • Endotoxin
  • Livestock farming
  • Public health
  • Spatial modelling

Cite this

@article{aaebe31f9b7a461cb4906e3d0d534a06,
title = "Endotoxin and particulate matter emitted by livestock farms and respiratory health effects in neighboring residents",
abstract = "Background: Living in livestock-dense areas has been associated with health effects, suggesting airborne exposures to livestock farm emissions to be relevant for public health. Livestock farm emissions involve complex mixtures of various gases and particles. Endotoxin, a pro-inflammatory agent of microbial origin, is a constituent of livestock farm emitted particulate matter (PM) that is potentially related to the observed health effects. Quantification of livestock associated endotoxin exposure at residential addresses in relation to health outcomes has not been performed earlier. Objectives: We aimed to assess exposure-response relations for a range of respiratory endpoints and atopic sensitization in relation to livestock farm associated PM10 and endotoxin levels. Methods: Self-reported respiratory symptoms of 12,117 persons participating in a population-based cross-sectional study were analyzed. For 2494 persons, data on lung function (spirometry) and serologically assessed atopic sensitization was additionally available. Annual-average PM10 and endotoxin concentrations at home addresses were predicted by dispersion modelling and land-use regression (LUR) modelling. Exposure-response relations were analyzed with generalized additive models. Results: Health outcomes were generally more strongly associated with exposure to livestock farm emitted endotoxin compared to PM10. An inverse association was observed for dispersion modelled exposure with atopic sensitization (endotoxin: p =.004, PM10: p =.07) and asthma (endotoxin: p =.029, PM10: p =.022). Prevalence of respiratory symptoms decreased with increasing endotoxin concentration at the lower range, while at the higher range prevalence increased with increasing concentration (p <.05). Associations between lung function parameters with exposure to PM10 and endotoxin were not statistically significant (p >.05). Conclusions: Exposure to livestock farm emitted particulate matter is associated with respiratory health effects and atopic sensitization in non-farming residents. Results indicate endotoxin to be a potentially plausible etiologic agent, suggesting non-infectious aspects of microbial emissions from livestock farms to be important with respect to public health.",
keywords = "Air pollution, Emissions, Endotoxin, Livestock farming, Public health, Spatial modelling",
author = "{de Rooij}, {Myrna M.T.} and Smit, {Lidwien A.M.} and Erbrink, {Hans J.} and Hagenaars, {Thomas J.} and Gerard Hoek and Ogink, {Nico W.M.} and Albert Winkel and Heederik, {Dick J.J.} and Wouters, {Inge M.}",
year = "2019",
month = "11",
day = "1",
doi = "10.1016/j.envint.2019.105009",
language = "English",
volume = "132",
journal = "Environment International",
issn = "0160-4120",
publisher = "Elsevier",

}

Endotoxin and particulate matter emitted by livestock farms and respiratory health effects in neighboring residents. / de Rooij, Myrna M.T.; Smit, Lidwien A.M.; Erbrink, Hans J.; Hagenaars, Thomas J.; Hoek, Gerard; Ogink, Nico W.M.; Winkel, Albert; Heederik, Dick J.J.; Wouters, Inge M.

In: Environment International, Vol. 132, 105009, 01.11.2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Endotoxin and particulate matter emitted by livestock farms and respiratory health effects in neighboring residents

AU - de Rooij, Myrna M.T.

AU - Smit, Lidwien A.M.

AU - Erbrink, Hans J.

AU - Hagenaars, Thomas J.

AU - Hoek, Gerard

AU - Ogink, Nico W.M.

AU - Winkel, Albert

AU - Heederik, Dick J.J.

AU - Wouters, Inge M.

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Background: Living in livestock-dense areas has been associated with health effects, suggesting airborne exposures to livestock farm emissions to be relevant for public health. Livestock farm emissions involve complex mixtures of various gases and particles. Endotoxin, a pro-inflammatory agent of microbial origin, is a constituent of livestock farm emitted particulate matter (PM) that is potentially related to the observed health effects. Quantification of livestock associated endotoxin exposure at residential addresses in relation to health outcomes has not been performed earlier. Objectives: We aimed to assess exposure-response relations for a range of respiratory endpoints and atopic sensitization in relation to livestock farm associated PM10 and endotoxin levels. Methods: Self-reported respiratory symptoms of 12,117 persons participating in a population-based cross-sectional study were analyzed. For 2494 persons, data on lung function (spirometry) and serologically assessed atopic sensitization was additionally available. Annual-average PM10 and endotoxin concentrations at home addresses were predicted by dispersion modelling and land-use regression (LUR) modelling. Exposure-response relations were analyzed with generalized additive models. Results: Health outcomes were generally more strongly associated with exposure to livestock farm emitted endotoxin compared to PM10. An inverse association was observed for dispersion modelled exposure with atopic sensitization (endotoxin: p =.004, PM10: p =.07) and asthma (endotoxin: p =.029, PM10: p =.022). Prevalence of respiratory symptoms decreased with increasing endotoxin concentration at the lower range, while at the higher range prevalence increased with increasing concentration (p <.05). Associations between lung function parameters with exposure to PM10 and endotoxin were not statistically significant (p >.05). Conclusions: Exposure to livestock farm emitted particulate matter is associated with respiratory health effects and atopic sensitization in non-farming residents. Results indicate endotoxin to be a potentially plausible etiologic agent, suggesting non-infectious aspects of microbial emissions from livestock farms to be important with respect to public health.

AB - Background: Living in livestock-dense areas has been associated with health effects, suggesting airborne exposures to livestock farm emissions to be relevant for public health. Livestock farm emissions involve complex mixtures of various gases and particles. Endotoxin, a pro-inflammatory agent of microbial origin, is a constituent of livestock farm emitted particulate matter (PM) that is potentially related to the observed health effects. Quantification of livestock associated endotoxin exposure at residential addresses in relation to health outcomes has not been performed earlier. Objectives: We aimed to assess exposure-response relations for a range of respiratory endpoints and atopic sensitization in relation to livestock farm associated PM10 and endotoxin levels. Methods: Self-reported respiratory symptoms of 12,117 persons participating in a population-based cross-sectional study were analyzed. For 2494 persons, data on lung function (spirometry) and serologically assessed atopic sensitization was additionally available. Annual-average PM10 and endotoxin concentrations at home addresses were predicted by dispersion modelling and land-use regression (LUR) modelling. Exposure-response relations were analyzed with generalized additive models. Results: Health outcomes were generally more strongly associated with exposure to livestock farm emitted endotoxin compared to PM10. An inverse association was observed for dispersion modelled exposure with atopic sensitization (endotoxin: p =.004, PM10: p =.07) and asthma (endotoxin: p =.029, PM10: p =.022). Prevalence of respiratory symptoms decreased with increasing endotoxin concentration at the lower range, while at the higher range prevalence increased with increasing concentration (p <.05). Associations between lung function parameters with exposure to PM10 and endotoxin were not statistically significant (p >.05). Conclusions: Exposure to livestock farm emitted particulate matter is associated with respiratory health effects and atopic sensitization in non-farming residents. Results indicate endotoxin to be a potentially plausible etiologic agent, suggesting non-infectious aspects of microbial emissions from livestock farms to be important with respect to public health.

KW - Air pollution

KW - Emissions

KW - Endotoxin

KW - Livestock farming

KW - Public health

KW - Spatial modelling

U2 - 10.1016/j.envint.2019.105009

DO - 10.1016/j.envint.2019.105009

M3 - Article

VL - 132

JO - Environment International

JF - Environment International

SN - 0160-4120

M1 - 105009

ER -