Microspheres having a particle size of 50 nm to 1 nm and a polydispersity of less than 40%, consisting of a chemically cross-linked starch shell containing an active ingredient, are obtained by preparing an oil-in-water emulsion of the active ingredient in a hydrophobic phase and starch or a dispersion of a solid active ingredient and starch in water, incorporating the oil-in-water emulsion or solid dispersion in an outer hydrophobic phase, particles of the oil-in-water emulsion or solid dispersion being formed in the outer hydrophobic phase, cross-linking the starch or derivative thereof and removing the outer hydrophobic phase if desired.
|Publication status||Published - 14 Jan 1999|
Gotlieb, K. F., van Schijndel, R. J. G., & van Soest, J. J. G. (1999). Encapsulation of active ingredients. (Patent No. WO9901214). https://worldwide.espacenet.com/publicationDetails/originalDocument?CC=WO&NR=9901214A1&KC=A1&FT=D&ND=3&date=19990114&DB=EPODOC&locale=en_EP