Enantioselective synthesis of highly functionalised cyclohexanones starting from R-(-)-Carvone.

T.M. Meulemans, G.A. Stork, B.J.M. Jansen, Æ. de Groot

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Abstract

Copper (I) catalysed conjugate addition of methylmagnesium iodide to R-(−)-carvone and trapping the enolate as its trimethylsilyl enol ether, followed by a trityl perchlorate (TrClO4) catalysed Mukaiyama-aldol reaction, is an efficient method for the preparation of highly functionalised cyclohexanones which can be used as starting compounds in the total syntheses of enantiomerically pure clerodanes.
Original languageEnglish
Pages (from-to)6566-6568
JournalTetrahedron Letters
Volume39
Issue number36
DOIs
Publication statusPublished - 1998

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