Emerging animal viruses in China, from discovery to control measures

Qiuhong Miao

Research output: Thesisinternal PhD, WU

Abstract

Frequent outbreaks of emerging animal viruses cause great economic losses and pose potential risks for human health. In this thesis, emerging animal viruses that affect the veterinary industry and have a significant economic burden in China and beyond was focused, including Peste des Petits ruminants virus (PPRV), Rabbit hemorrhagic disease virus (RHDV2), and Getah virus (GETV). By studying different aspects of virus infection in relation to innate immunity and a focus on virus-like particle (VLP) vaccine development, important knowledge for future control of emerging animal viruses will be generated. This thesis aimed to understand how to control emerging animal viruses, thereby focusing on several aspects of virus-induced innate immunity in PPRV infection in goats, including the function of caprine MAVS and the ISG, BST2/tetherin, and how PPRV counteracted these factors. In addition, promising vaccine candidates were developed against RHDV1 and RHDV2 in rabbits, and against GETV. Over all, the research presented in this thesis contributed to the understanding of virus-host interactions and provided candidates for veterinary vaccine development.

Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Wageningen University
Supervisors/Advisors
  • van Oers, Monique, Promotor
  • Liu, G., Promotor, External person
  • Pijlman, Gorben, Promotor
Award date11 Oct 2021
Place of PublicationWageningen
Publisher
Print ISBNs9789463959452
DOIs
Publication statusPublished - 11 Oct 2021

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