Efficacy of a topically administered combination of emodepside and praziquantel against mature and immature Ancylostoma tubaeforme in domestic cats

G. Altreuther, F.H.M. Borgsteede, J. Buch, S.D. Charles, L. Cruthers, C. Epe, D.R. Young, K.J. Krieger

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    Abstract

    This paper reports the efficacy of emodepside/praziquantel spot¿on (Profender®, Bayer AG, Leverkusen, Germany), a novel broadspectrum anthelmintic for dermal application, against L4 larvae and immature adult and adult stages of Ancylostoma tubaeforme in cats. The formulation contains 2.14% (w/w) emodepside and 8.58% (w/v) praziquantel, with emodepside being active against gastrointestinal nematodes and praziquantel against cestodes. Five randomized, blinded and controlled laboratory studies demonstrated 100% efficacy of emodepside/praziquantel spot¿on against mature A. tubaeforme and an efficacy of >95% and >97%, respectively, against L4 larvae and immature adults (based on worm counts after necropsy) at approximately the minimum proposed dose rate in cats of 3.0 mg emodepside and 12.0 mg praziquantel/kg body weight. No adverse reactions to the treatment were observed. It is concluded that emodepside/praziquantel spot¿on is an effective and safe treatment against infections with mature and immature A. tubaeforme. Emodepside/praziquantel spot¿on will considerably facilitate the treatment of cats against nematodes and cestodes compared with orally administered preparations
    Original languageEnglish
    Pages (from-to)S51-S57
    JournalParasitology Research
    Volume97
    Issue numberSuppl. 1
    DOIs
    Publication statusPublished - 2005

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  • Cite this

    Altreuther, G., Borgsteede, F. H. M., Buch, J., Charles, S. D., Cruthers, L., Epe, C., Young, D. R., & Krieger, K. J. (2005). Efficacy of a topically administered combination of emodepside and praziquantel against mature and immature Ancylostoma tubaeforme in domestic cats. Parasitology Research, 97(Suppl. 1), S51-S57. https://doi.org/10.1007/s00436-005-1444-1