Effects of structure on hydrogel microbead function

Pauline van Leusden

Research output: Thesisinternal PhD, WU

Abstract

Hydrogel microbeads are capable of trapping, protecting and delivering components. We investigated how different production parameters influenced the microstructure of protein and polysaccharide hydrogel microbeads, and how that in turn influenced the functional properties of the microbeads as encapsulation devices in various systems. We found that by changing the production method and the hydrocolloid type and density we could create a variety of structures with different strengths, breakdown patterns and diffusivity profiles. Most importantly, the functionality of the hydrogel microbeads is not dependent on the individual production parameters, but on a system in which the hydrogel matrix, the diffusing compound moving into or out of the microbead, and the environment in which the microbead is present, all play varying but important roles in the complete system. The hydrogel microbead by itself is a viable encapsulation device but may also be the basis for a more complex encapsulation system in which several components may be encapsulated together and which may be triggered to release by outside influences.

Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Wageningen University
Supervisors/Advisors
  • van der Linden, Erik, Promotor
  • Sagis, Leonard, Promotor
  • Postema, M.A.B., Co-promotor, External person
  • Hartog, G.J.M., Co-promotor, External person
Award date4 Jul 2018
Place of PublicationWageningen
Publisher
Print ISBNs9789463438568
DOIs
Publication statusPublished - 2018

Fingerprint

hydrocolloids
encapsulation
diffusivity
microstructure
functional properties
trapping
polysaccharides
proteins

Cite this

van Leusden, P. (2018). Effects of structure on hydrogel microbead function. Wageningen: Wageningen University. https://doi.org/10.18174/446239
van Leusden, Pauline. / Effects of structure on hydrogel microbead function. Wageningen : Wageningen University, 2018. 136 p.
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van Leusden, P 2018, 'Effects of structure on hydrogel microbead function', Doctor of Philosophy, Wageningen University, Wageningen. https://doi.org/10.18174/446239

Effects of structure on hydrogel microbead function. / van Leusden, Pauline.

Wageningen : Wageningen University, 2018. 136 p.

Research output: Thesisinternal PhD, WU

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T1 - Effects of structure on hydrogel microbead function

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AB - Hydrogel microbeads are capable of trapping, protecting and delivering components. We investigated how different production parameters influenced the microstructure of protein and polysaccharide hydrogel microbeads, and how that in turn influenced the functional properties of the microbeads as encapsulation devices in various systems. We found that by changing the production method and the hydrocolloid type and density we could create a variety of structures with different strengths, breakdown patterns and diffusivity profiles. Most importantly, the functionality of the hydrogel microbeads is not dependent on the individual production parameters, but on a system in which the hydrogel matrix, the diffusing compound moving into or out of the microbead, and the environment in which the microbead is present, all play varying but important roles in the complete system. The hydrogel microbead by itself is a viable encapsulation device but may also be the basis for a more complex encapsulation system in which several components may be encapsulated together and which may be triggered to release by outside influences.

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van Leusden P. Effects of structure on hydrogel microbead function. Wageningen: Wageningen University, 2018. 136 p. https://doi.org/10.18174/446239